On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
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Peyer’s patches (PPs) support the production of intestinal IgA. Induction of IgA+ cells in PPs requires interactions between B cells and conventional dendritic cells type 2 (cDC2s) in the subepithelial dome (SED). We found that cDC2s express GPR35, a receptor that promotes migration to 5-hydroxyindoleacetic acid (5-HIAA). In mice lacking GPR35, there was a loss of cDC2s from the SED and of IgA+ cells. Mast cells were present in the SED and ablation of 5-HIAA production in mast cells phenocopied the absence of GPR35. Thus, mast cell-guided positioning of GPR35+ cDC2s in the SED supports induction of intestinal IgA responses.
