OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Peyer’s patches (PPs) support the production of intestinal IgA. Induction of IgA+ cells in PPs requires interactions between B cells and conventional dendritic cells type 2 (cDC2s) in the subepithelial dome (SED). We found that cDC2s express GPR35, a receptor that promotes migration to 5-hydroxyindoleacetic acid (5-HIAA). In mice lacking GPR35, there was a loss of cDC2s from the SED and of IgA+ cells. Mast cells were present in the SED and ablation of 5-HIAA production in mast cells phenocopied the absence of GPR35. Thus, mast cell-guided positioning of GPR35+ cDC2s in the SED supports induction of intestinal IgA responses.
