Oxford Events, the new replacement for OxTalks, will launch on 16th March. From now until the launch of Oxford Events, new events cannot be published or edited on OxTalks while all existing records are migrated to the new platform. The existing OxTalks site will remain available to view during this period.
From 16th, Oxford Events will launch on a new website: events.ox.ac.uk, and event submissions will resume. You will need a Halo login to submit events. Full details are available on the Staff Gateway.
T cell metabolism shapes immune function, but how CD8+ T cell flexibility relates to immunotherapy response is unclear. Using spatial proteomics, we map a metabolic continuum of tumor-infiltrating CD8+ T cells defined by differential fermentative and oxidative engagement. These states display distinct immune interactomes and metabolic niches, reflecting lineage-transcending regulator patterns. Metabolic flexibility, such as lactate utilization, characterized responder tumors and correlated with enriched memory and progenitor-exhausted signatures in transcriptomic datasets. Machine learning integration of metabolic and immunological profiles predicted checkpoint blockade response. Our findings position metabolic flexibility, not abundance, as central to durable antitumor immunity.
