OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
T cell metabolism shapes immune function, but how CD8+ T cell flexibility relates to immunotherapy response is unclear. Using spatial proteomics, we map a metabolic continuum of tumor-infiltrating CD8+ T cells defined by differential fermentative and oxidative engagement. These states display distinct immune interactomes and metabolic niches, reflecting lineage-transcending regulator patterns. Metabolic flexibility, such as lactate utilization, characterized responder tumors and correlated with enriched memory and progenitor-exhausted signatures in transcriptomic datasets. Machine learning integration of metabolic and immunological profiles predicted checkpoint blockade response. Our findings position metabolic flexibility, not abundance, as central to durable antitumor immunity.
