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The DOCK8 Immunodeficiency Syndrome is characterised by a failure to generate long-term T cell dependent protective immunity, associated with absent affinity maturation. Our findings suggest that the absence of DOCK8 causesdefects downstream of the B cell receptor, which result in a failure of B-T cross-talk when antigen is limiting. These effects are associated with reduced B cell survival, which is amplified in the germinal centre.
