On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
If you have any questions, please contact halo@digital.ox.ac.uk
How lipidome changes support CD8+ effector T (Teff) cell differentiation is not well understood. We found that two separate phosphoinositde (PIPn) pools, marked by different acyl chain compositions, drive important signalling events at specific stages of Teff cell differentiation. Teff cell PIPn signaling was maintained by the rapid and continuous de novo saturated PI synthesis from glucose, directly tying the nutrient environment with Teff signaling. Saturated PI synthesis was increased in CD8+ TILs, and CDIPT, which catalyses the final enzymatic step in de novo PI synthesis, was required for CD8+ TIL antitumor fitness and function. T cells with improved antitumor function following checkpoint inhibitor therapy synthesized more saturated PIPn in mouse and human melanoma.
