Oxford Events, the new replacement for OxTalks, will launch on 16th March. From now until the launch of Oxford Events, new events cannot be published or edited on OxTalks while all existing records are migrated to the new platform. The existing OxTalks site will remain available to view during this period.
From 16th, Oxford Events will launch on a new website: events.ox.ac.uk, and event submissions will resume. You will need a Halo login to submit events. Full details are available on the Staff Gateway.
How lipidome changes support CD8+ effector T (Teff) cell differentiation is not well understood. We found that two separate phosphoinositde (PIPn) pools, marked by different acyl chain compositions, drive important signalling events at specific stages of Teff cell differentiation. Teff cell PIPn signaling was maintained by the rapid and continuous de novo saturated PI synthesis from glucose, directly tying the nutrient environment with Teff signaling. Saturated PI synthesis was increased in CD8+ TILs, and CDIPT, which catalyses the final enzymatic step in de novo PI synthesis, was required for CD8+ TIL antitumor fitness and function. T cells with improved antitumor function following checkpoint inhibitor therapy synthesized more saturated PIPn in mouse and human melanoma.
