OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
How lipidome changes support CD8+ effector T (Teff) cell differentiation is not well understood. We found that two separate phosphoinositde (PIPn) pools, marked by different acyl chain compositions, drive important signalling events at specific stages of Teff cell differentiation. Teff cell PIPn signaling was maintained by the rapid and continuous de novo saturated PI synthesis from glucose, directly tying the nutrient environment with Teff signaling. Saturated PI synthesis was increased in CD8+ TILs, and CDIPT, which catalyses the final enzymatic step in de novo PI synthesis, was required for CD8+ TIL antitumor fitness and function. T cells with improved antitumor function following checkpoint inhibitor therapy synthesized more saturated PIPn in mouse and human melanoma.
