Oxford Events, the new replacement for OxTalks, will launch on 16th March. The two-week OxTalks freeze period starts on Monday 2nd March. During this time, there will be no facility to publish or edit events. The existing OxTalks site will remain available to view during this period. Once Oxford Events launches, you will need a Halo login to submit events. Full details are available on the Staff Gateway.
A single T cell receptor (TCR) can recognise up to one million different peptide ligands with varying affinities. We have developed a novel high-throughput Surface Plasmon Resonance (SPR) method to measure the affinity of hundreds of TCR/pMHC interactions in a single experiment. Using this method, we demonstrate that T activation correlates with ligand affinity. Furthermore, we have shown that modifying co-signalling receptors can selectively abolish T cell activation against low-affinity peptide. Overall, these findings demonstrate that T cells can be engineered to be less cross-reactive, which has important implications for enhancing the safety of adoptive T cell therapies.
