OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Upon tissue damage, inflammatory signals and chemoattractants drive leukocyte recruitment and initiate host defense mechanisms. These are particularly crucial in injured epithelia to protect against environmental threats and pathogen invasion. Our research has demonstrated the central role of cytosolic phospholipase A2 (cPLA2)-dependent eicosanoid production in this process. Triggered by nuclear swelling and damage-induced Ca2+ signaling, cPLA2 and 5-lipoxygenase (5-LOX) contribute to the production of inflammatory eicosanoids. To further elucidate chemoattractant dynamics, in a project called „Inflamapping” we have begun developing a suite of GPCR-based fluorescent biosensors to visualize gradients of key chemoattractants, including LTB4, fMLP, and C5a.
