OxTalks will soon be transitioning to Oxford Events (full details are available on the Staff Gateway). A two-week publishing freeze is expected to start before the end of Hilary Term to allow all future events to be migrated to the new platform. During this period, you will not be able to submit or edit events on OxTalks. The exact freeze dates will be confirmed on the Staff Gateway and via email to identified OxTalks users.
If you have any questions, please contact halo@digital.ox.ac.uk
The emergence of the MHC I-like gene MR1 in the ancestor of mammals enabled T cells to see new ligands: small metabolites derived either from bile acids or from the microbial riboflavin pathway. MR1 remained highly conserved and monomorphic during evolution, and MR1-restricted T cells (MAIT cells) retained an innate-like program shared across species, indicating non-redundant functions linked to this antigenic specificity. Our lab investigates how MAIT ligands, which are constantly produced by the microbiota, shape MAIT cell development and function.
