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Cancer progression is an evolutionary process involving the sequential occurrence of key genetic alterations known as drivers. In prostate cancer, progression to metastasis requires multiple driver alterations, although the type and order of these invariably differs between patients. In this talk we describe how the union of multiple genomic analyses reveals that divergent evolution, mediated by drivers that induce dysregulation of androgen receptor DNA binding, results in two distinct subtypes. Our findings unify many previous molecular groupings in prostate cancer and provide a powerful new paradigm for cancer stratification.
