OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Cancer progression is an evolutionary process involving the sequential occurrence of key genetic alterations known as drivers. In prostate cancer, progression to metastasis requires multiple driver alterations, although the type and order of these invariably differs between patients. In this talk we describe how the union of multiple genomic analyses reveals that divergent evolution, mediated by drivers that induce dysregulation of androgen receptor DNA binding, results in two distinct subtypes. Our findings unify many previous molecular groupings in prostate cancer and provide a powerful new paradigm for cancer stratification.
