TrUST is a quasi-experimental study using a mixed-methods approach to study the benefits of cable cars for vulnerable populations. The aims of the study were: to 1) assess the effects of its implementation on the environmental and social determinants of health, physical activity, and health outcomes; and 2) use citizen science methods to identify, prioritize, and communicate the most salient negative and positive features impacting liveability. Outcomes related to environmental and social determinants of health as well as health outcomes were assessed using questionnaires, portable devices (air pollution exposure), and direct observation (parks). After the implementation of TransMiCable, residents reported higher travel time reductions and higher satisfaction with transport compared to control group. Individual physical activity levels did not change after the implementation of the cable car. However, observed physical activity levels among women in a renovated park increased. The citizen science model showed that main facilitators of liveability after the implementation of TransMiCable included parks quality, community networks, shorter travel times, and security improvements. Emerging positive themes included the perceived transformation of the neighbourhood’s social stigma and increased free time. Stakeholders highlighted that the evaluation revealed the potential impacts of transportation and urban interventions on liveability and health. TrUST is innovative in its use of a mixed-methods, and interdisciplinary research approach, and in its systematic engagement of citizens and policymakers throughout the design and evaluation process.