Molecular mechanisms of cortical interneuron diversity and plasticity

To arrange individual meetings with Prof. Oscar Marin, please contact Matthew Buchan (

GABAergic interneurons play crucial roles in the regulation of neural circuit activity in the cerebral cortex. A hallmark of cortical interneurons is their remarkable structural and functional diversity, yet the molecular determinants and the precise timing underlying their diversification remain largely unknown. The search for mechanisms controlling the diversity of GABAergic interneurons has primarily focused on the analysis of transcriptional programs in their progenitor cells. In this talk, I will describe how transcriptional programmes, both during embryonic development and in the postnatal brain, regulate the identity of specific classes of cortical interneurons, thereby contributing to the generation of neuronal diversity in the cerebral cortex.