OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Immune cells experience large deformation events while paroling their environment. These cell shape changes arise from the continuous physical constraints encountered during migration within tissues and organs. It has become increasingly clear that these cells can survive and adapt to changes in cell shape using dedicated shape-sensing pathways. However, how shape sensing impacts their behavior and function remains largely unknown. During my seminar, I will show unpublished data highlighting that the nuclear shape changes experienced by immune cells define their migratory behavior and immunoregulatory properties, revealing the contribution of the physical properties of tissues to tuning of the balance between tolerance an immunity.
