OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
All cells must continuously manage reactivity – the chemistry that sustains life but also threatens it. Endogenous aldehydes such as formaldehyde are unavoidable byproducts of essential metabolism that challenge genome integrity, while uncontrolled lipid peroxidation can lead to ferroptotic cell death when antioxidant capacity becomes compromised. Both stresses are mainly handled by the same nucleophilic molecule: glutathione, creating a fundamental trade-off that must be resolved. In this lecture, I will discuss how cancer cells rewire their nucleophilic metabolism to navigate this conflict, prioritizing aldehyde detoxification or ferroptosis resistance according to their oncogenic landscape.
