On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
If you have any questions, please contact halo@digital.ox.ac.uk
All cells must continuously manage reactivity – the chemistry that sustains life but also threatens it. Endogenous aldehydes such as formaldehyde are unavoidable byproducts of essential metabolism that challenge genome integrity, while uncontrolled lipid peroxidation can lead to ferroptotic cell death when antioxidant capacity becomes compromised. Both stresses are mainly handled by the same nucleophilic molecule: glutathione, creating a fundamental trade-off that must be resolved. In this lecture, I will discuss how cancer cells rewire their nucleophilic metabolism to navigate this conflict, prioritizing aldehyde detoxification or ferroptosis resistance according to their oncogenic landscape.
