For our next talk, in the BDI/CHG (gen)omics Seminar series, we will be hearing from Hannah Currant, Wellcome Early Career Fellow, NDWRH, Big Data Institute. We’re delighted to host Hannah in what promises to be a great talk!

Date: Tuesday 25 November
Time: 9:30 – 10:30
Location: BDI/OxPop seminar room 0

Talk title: Investigating the impact of genetic variation on the hypothalamic–pituitary–gonadal axis

Abstract: The hypothalamic-pituitary-gonadal (HPG) axis refers to the system of interaction and coordination between the hypothalamus, pituitary and gonadal glands that are involved in the development and regulation of the reproductive system. The axis is involved in temporal variation in reproductive hormones across reproductive ageing, and in females, cyclical variation with the menstrual cycle. Disruptions to the HPG axis can lead to reproductive pathologies including infertility. This talk will cover several projects that all look to investigate the impact of genetic variation on the function of the HPG axis. We conducted a genome-wide association study of the morphology of the hypothalamus and pituitary gland using MRI-derived quantitative phenotypes in the UK Biobank. We are investigating the genetics underlying Idiopathic Hypogonadotropic Hypogonadism, which causes infertility, in an international cohort meta-analysis. And looking to the future we are investigating the variation in ovarian gene expression across reproductive ageing.

Biography: Hannah obtained a BSc in Molecular Biology from the University of St Andrews before completing her PhD at the University of Cambridge. There she undertook her research at the EMBL European Bioinformatics Institute (EMBL-EBI), focusing on the genetics of retinal morphology using image-derived phenotypes. She then received a Marie Skłodowska-Curie Actions Postdoctoral Fellowship to work at the University of Copenhagen on the genetics underlying morphology of neuroendocrine regions using MRI-derived phenotypes before moving to the Nuffield Department of Population Health at the University of Oxford. Hannah is now establishing her independent research group at the Nuffield Department of Women’s and Reproductive Health as a Wellcome Early Career Fellow.
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All members of the University are welcome to join, please let reception at BDI know you’re here for the seminar and sign-in. We hope you can join us!

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As a reminder, the (gen)omics seminar series runs every other Tuesday morning and is intended to increase interaction between individuals working in genomics across Oxford. We encourage in-person attendance where possible. There is time for discussion over, tea, coffee and pastries after the talks.

Hybrid Option:
Please note that these meetings are closed meetings and only open to members of the University of Oxford to encourage sharing of new and unpublished data. Please respect our speakers and do not share the link with anyone outside of the university.

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Passcode: vJ7i9cf3
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