OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Cardiac ventricular myocytes work continuously but have minimal intracellular energy reserves sufficient for less than 30 seconds of work. To compensate for this energetic vulnerability, rapid and accurate real-time ATP production is essential, regulated by a stringent feedback-control system. Half of the required feedback-control system has been elucidated and updated recently showing how cellular and mitochondrial [Ca2+] control mitochondrial ATP production. Here we present critical new information on the second half of the feedback-control system which senses the amounts of energy consumed and carbon-based food-stock processed by mitochondria to synthesize ATP. We show that the pivotal new sensor that enables this process is soluble adenylyl cyclase, which resides in the mitochondrial intermembrane space and drives additional ATP production by mitochondria through the activation of a novel signaling cascade.
