OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
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Proteins are generally assumed to be transported across membranes in an unfolded state. However, it is becoming increasingly apparent that there are also transporters dedicated to moving folded proteins through membranes. We have identified two such systems in bacteria. The Tat (twin-arginine translocation) system is found in the bacterial cytoplasmic membrane and conserved in some eukaryotic organelles. The Type 9 Secretion System is found in the outer membrane of bacteria from the Bacteroidetes superphylum. Both transport systems are essential virulence determinants in human pathogens. I will describe our latest data on these transport systems and show that they transport folded proteins by very different mechanisms.
