OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Ageing is emerging as a universal problem bringing formidable socioeconomic challenges. Studies on the mechanisms of ageing will facilitate our understanding of the process and will generate potential preventive strategies. Since no single ageing theory can satisfactorily explain all aspects of the ageing process, an integration of multiple theories on ageing is favored. The speaker will describe his latest studies on how two classical ageing hypotheses, persistent DNA damage and mitochondrial dysfunction, converge to explain premature ageing symptoms and contribute to neurological phenotypes in a series of ageing laboratory models. Emerging evidence suggests a critical role for DNA damage signalling from the nucleus to mitochondria (NM signalling) in regulating mitochondrial function and ageing. The interconnected roles of DNA damage, NAD+, and mitophagy will be explored in relation to ageing and neurodegenerative diseases, especially Alzheimer’s disease.
