Upregulation of long non-coding RNA NEAT1 and paraspeckles by lysosomal stress

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Upregulation of long non-coding RNA NEAT1 and paraspeckles by lysosomal stress

Abstract:

NEAT1 is a highly abundant long non-coding RNA that is an essential scaffold for the assembly of a class of nuclear ribonucleoprotein bodies called paraspeckles. Paraspeckles formation is elevated by a wide variety of cellular stressors and modulate cellular processes by sequestering proteins or RNA molecules. Importantly, abnormal NEAT1 expression is associated with serious diseases such as neurodegenerative disorders and cancer. In this talk I will present data suggesting a crosstalk between paraspeckles and lysosomes, which might be relevant in human pathologies.

Date: 18 May 2023, 13:00
Venue: This event is hybrid
Speaker: Dr Maria Perander (Department of Medical Biology, UiT The Arctic University of Norway)
Organising department: Nuffield Department of Women's and Reproductive Health
Organiser: Dr Karl Morten (Nuffield Department of Women's and Reproductive Health, University of Oxford)
Organiser contact email address: seminars@wrh.ox.ac.uk
Host: Dr Karl Morten (Nuffield Department of Women's and Reproductive Health, University of Oxford)
Booking required?: Recommended
Booking email: seminars@wrh.ox.ac.uk
Audience: Members of the University only
This talk features in the following public collections:
- Talks of Interest to Medical Sciences
- Talks of interest to the Nuffield Department of Women's & Reproductive Health
Editor: Isobel Way