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During this talk I will focus on the epidemiology, ecology, and evolution of the diarrhoeal disease, shigellosis, in the United Kingdom. Using a large national genomic surveillance dataset of Shigella sonnei (n=3,475) sampled over nearly two decades I will illustrate how we connect pathogen evolution to public health outcomes by drawing on two major unpublished studies from the group. Firstly, a phylodynamic study showing the differential epidemiology (including geospatial spread) of shigellosis in and outside of sexual transmission networks, including how the acquisition and fitness benefits provided by antimicrobial resistance (AMR) is influenced by bystander resistance in different demographic groups. And secondly, how we have leveraged our deep understanding of this genomic epidemiological framework of multimodal transmission for novel fundamental biological discovery; using bacterial Genome Wide Association Study to identify novel precursors of AMR in this WHO priority pathogen.
Professor Kate Baker
University of Cambridge
www.infectiousdisease.cam.ac.uk/staff/kate-baker
