On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
If you have any questions, please contact halo@digital.ox.ac.uk
The average affinity of specific antibodies increases dramatically over the course of an immune response. This increase is the result of a Darwinian process in which B lymphocytes undergo iterative cycles of random hypermutation of their immunoglobulin genes, followed by selective proliferation of clones bearing affinity-enhancing mutations. This evolutionary process takes place in highly dynamic microanatomical structures known as germinal centers, which arise within secondary lymphoid organs upon infection or immunization. Our work combines intravital multiphoton microscopy with mouse genetics to study how the dynamics of B and T lymphocytes within germinal centers shapes the evolution of the high-affinity antibodies that are crucial to protection from infectious disease.
