Mental illness is common and destructive. Worldwide, poor mental health directly affects one in four people, with many more experiencing negative physical health outcomes due to the impact of mental distress on non-psychological ailments. In order to address these challenges, it is imperative that older adults’ mental health perspectives and priorities are incorporated into research aims and study designs. The Precision Mental Health Project aims to work directly with community partners, policymakers, and older adults to inform a research portfolio that examines factors associated with positive mental health and resilience. This inter-disciplinary project takes a mixed-method approach, ranging from exploratory qualitative research on mental health perspectives to data-driven computational modelling of mental health risk phenotypes. This talk will provide an overview of some of the ongoing work on the Precision Mental Health project, the challenges presented by the COVID-19 pandemic, as well future directions for the project.