Identifying novel regulators of insulin-stimulated glucose uptake from ‘omics analyses

My group are primarily interested how insulin regulates the transport of glucose into fat and muscle tissues. This process is important for lowering blood glucose after a meal, and impaired insulin-stimulated glucose uptake (or insulin resistance) is a risk factor for a number of metabolic disease including type 2 diabetes. I will discuss how we have used genomics, proteomics and phosphoproteomics analyses to shed light on new regulators of insulin-stimulated glucose transport and how this process is dysregulated in insulin resistance.