During Michaelmas Term, OxTalks will be moving to a new platform (full details are available on the Staff Gateway).
For now, continue using the current page and event submission process (freeze period dates to be advised).
If you have any questions, please contact halo@digital.ox.ac.uk
David Pellman’s laboratory investigates how errors in cell division lead to catastrophic mutational events, genome instability, and cancer. His group has uncovered mechanisms linking nuclear architecture to chromothripsis and other major genomic rearrangements, revealing how abnormal nuclear structures contribute to tumour evolution. Their recent work explores how nuclear atypia can cause heritable changes in chromatin organisation and gene expression, advancing our understanding of genome instability in human disease.