During Michaelmas Term, OxTalks will be moving to a new platform (full details are available on the Staff Gateway).
For now, continue using the current page and event submission process (freeze period dates to be advised).
If you have any questions, please contact halo@digital.ox.ac.uk
Transporting small molecules across cell membranes is an essential process in cell physiology. The uptake
of glucose and the maintenance of intracellular pH are two fundamental processes carried out by most
cells. Here, I will present our multidisciplinary approach that has revealed important insights into the
mechanism of glucose (GLUT) uptake and Na+/H+ exchange, which are important transport systems for our
cells to utilize glucose as an energy source and for the regulation cytoplasmic and organellar pH. I will also
present our recent structural insights into a sperm-specific Na+/H+ exchanger regulated by voltage –
transforming the transporter into a signaling cascade that is essential in animals (metazoa) for sperm
motility and fertilization.
Nature (2024) 626: 963-974; Nature (2023) 623:193–201; Nature (2020) 578 (7794):321-325; Nature (2015)
526(7573):397-401; Nature (2013) 501(7468):573-7.venue.