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Dr Alexi Nott is a Lecturer in the Department of Brain Sciences at Imperial College London and a Group Leader in the UK Dementia Research Institute. His group utilizes nuclei isolation methods and genome-wide sequencing approaches to profile the epigenome of brain cell types using patient-derived archived tissue. Functional interrogation of disease-associated gene regulatory regions is explored using CRISPR DNA-editing technology of pluripotent stem cells derived into brain cell types. Using a combination of these approaches, Alexi’s research examines how genetic risk contributes to age-related brain disorders.
