During Michaelmas Term, OxTalks will be moving to a new platform (full details are available on the Staff Gateway).
For now, continue using the current page and event submission process (freeze period dates to be advised).
If you have any questions, please contact halo@digital.ox.ac.uk
We discovered that during the early immune contraction phase of an acute infection with lymphocytic choriomeningitis virus, 2D TCR–pMHC affinity of TCR transgenic P14 T cells increased more for cells from the splenic red pulp (RP) than the white pulp (WP). This difference was governed by regulatory T cells and TGF-β. The increased 2D affinity of RP cells correlated with their increased ability to kill target cells and to recognize a CTL escape epitope. Memory precursors from WP preferentially developed into long-term memory cells as compared to cells from RP, despite expression of the same memory markers.