Are most published research findings false? Why should we care? And is there anything we can do about it? This talk will give an overview of some practical solutions such as open science and some good research practices that can help make research findings more robust. There are a number of solutions that can be implemented by individual researchers, and there are wider issues, for example around skills training and incentives, that require cultural change. The activities of the cross-divisional group Reproducible Research Oxford will also be outlined.