On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
If you have any questions, please contact halo@digital.ox.ac.uk
The brain is a metabolically vulnerable and demanding organ that suffers acute degradation in performance when fuel is restricted. In recent years the Ryan lab has been dissecting the molecular basis of local ATP production in nerve terminals and discovered that many of the genetic drivers of Parkinsonism impact either the efficacy of ATP production or create undue metabolic burdens at synapses. We carried out a genetic suppressor screen for metabolically compromised synapse function and determined that PGK-1, the first ATP producing enzyme in glycolysis, is rate limiting and that modest changes in its activity confer strong protection against metabolic lesions, including those driven by certain PARK genes.
