Oxford Events, the new replacement for OxTalks, will launch on 16th March. The two-week OxTalks freeze period starts on Monday 2nd March. During this time, there will be no facility to publish or edit events. The existing OxTalks site will remain available to view during this period. Once Oxford Events launches, you will need a Halo login to submit events. Full details are available on the Staff Gateway.
The brain is a metabolically vulnerable and demanding organ that suffers acute degradation in performance when fuel is restricted. In recent years the Ryan lab has been dissecting the molecular basis of local ATP production in nerve terminals and discovered that many of the genetic drivers of Parkinsonism impact either the efficacy of ATP production or create undue metabolic burdens at synapses. We carried out a genetic suppressor screen for metabolically compromised synapse function and determined that PGK-1, the first ATP producing enzyme in glycolysis, is rate limiting and that modest changes in its activity confer strong protection against metabolic lesions, including those driven by certain PARK genes.
