OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
GWAS variants pose an incredible opportunity to discover new drug targets as they are the genetic anchor to the disease-causing biological processes. In my talk, I will present how my team utilises a toolkit of genomics approaches coupled with immune phenotyping at scale to link disease genes to dysregulated cell functions.
We used single-cell eQTL mapping to define gene expression regulation during CD4+ T cell activation time course. We identified that disease variants colocalised with genes dynamically regulated during T-cell activation, i.e. genes whose eQTL effects manifested at specific activation time points. We are following up on the effects of eQTL genes colocalising with disease variants using CRISPR approaches coupled with rich phenotypic cell screens and high-content imaging to enable multi-modal profiling of immune cell biology at scale.
