The 2013-2016 West African Ebola virus outbreak had devastating effects on the local region. However, the large number of Ebola virus disease cases has allowed researchers to assess; the efficacy of novel vaccines, characteristics of naturally acquired immunity and the existence of sub-symptomatic infections. Additionally, as it was the most extensively sequenced outbreak in history it has provided opportunities to assess virus mutation patterns and develop tools to support molecular epidemiology. The seminar will include an overview of a unique longitudinal analysis of two cohorts of survivors in Guinea and compare naturally acquired and vaccine induced immunity. Aspects of the utility of real-time field sequencing of EBOV in an outbreak setting will also be described.