OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Secrets of heart regeneration revealed by comparative analyses in regenerative vs. non-regenerative models
Our laboratory performs comparative analyses in animals capable or incapable of heart regeneration to understand the cellular and molecular bases of this process. Particularly, zebrafish display a distinct ability to regenerate their heart following injury. However, this ability is not shared by another teleost, the medaka. Transcriptomic profiling revealed major differences in immune cell dynamics and gene expression between these models after cardiac injury. Functional experiments further showed that macrophage heterogeneity and functions are essential for zebrafish heart regeneration, while modulating immune response may enhance immune cell function and promote neovascularization, neutrophil clearance, cardiomyocyte proliferation, and scar resolution in medaka. Altogether, our research gains insights into the complex role of the immune response during heart regeneration and serves as a platform to identify and test novel regulators for therapeutic development.
