OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Achieving a graft-versus-leukemia (GVL) effect while suppressing graft versus host disease (GVHD) is the ultimate goal for allogeneic hematopoietic cell transplantation. Circulating CD8 regulatory T cells (Treg) that are capable of immunosuppression and cytolysis are rare. Therefore, we developed a protocol to generate human CD8 induced Tregs that are expansile and possess dual CD8 CTL cytotoxicity, consistent with their cell surface and intracellular expression patterns. When transduced with a chimeric antigen receptor, CD8 iTregs and cytotoxic T cells are equally cytolytic against their targets in vitro and in vivo, reflecting their dual function. Mechanism(s) underlying these properties will be discussed.
