Oxford Events, the new replacement for OxTalks, will launch on 16th March. From now until the launch of Oxford Events, new events cannot be published or edited on OxTalks while all existing records are migrated to the new platform. The existing OxTalks site will remain available to view during this period.
From 16th, Oxford Events will launch on a new website: events.ox.ac.uk, and event submissions will resume. You will need a Halo login to submit events. Full details are available on the Staff Gateway.
Achieving a graft-versus-leukemia (GVL) effect while suppressing graft versus host disease (GVHD) is the ultimate goal for allogeneic hematopoietic cell transplantation. Circulating CD8 regulatory T cells (Treg) that are capable of immunosuppression and cytolysis are rare. Therefore, we developed a protocol to generate human CD8 induced Tregs that are expansile and possess dual CD8 CTL cytotoxicity, consistent with their cell surface and intracellular expression patterns. When transduced with a chimeric antigen receptor, CD8 iTregs and cytotoxic T cells are equally cytolytic against their targets in vitro and in vivo, reflecting their dual function. Mechanism(s) underlying these properties will be discussed.
