OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
The regulated phosphorylation and de-phosphorylation of the alpha subunit of translation initiation factor 2 (eIF2) potently regulates global and gene-specific mRNA translation and thereby broadly affects proteostasis in diverse physiological and pathological settings. Phosphorylated eIF2 is a convergence point for several stress response pathways and its downstream effector processes are known as the integrated stress response (or ISR). In this talk I will review recent advances in our understanding of the ISR and its role in proteostasis.
