On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
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T cell-dependent immunity commences with T-cell antigen receptor (TCR-CD3) signalling. TCR-CD3 features unique ligand recognition, signalling modalities and convoluted quaternary structure, diverging considerably from “classic”, evolutionary ancient membrane receptors of simpler molecular design and univocal relationship to ligands. TCR-CD3 recognises with exceptional sensorial and discriminatory ability antigens of varying structure, quantity and detection context. Given such a complexity, it is perhaps unsurprising that controversy exists on how TCR-CD3 works. I will report new data suggesting an allosteric mechanism by which TCR-CD3 transmits signals across the plasma membrane that should improve our understanding of how T cell activation begins.
