On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
If you have any questions, please contact halo@digital.ox.ac.uk
Haematopoietic stem cells (HSCs) develop in the aorta-gonad-mesonephros (AGM) region. In utero development significantly reduces accessibility of the mouse embryo for analysis. We established AGM in vitro systems that can recapitulate in vivo HSC development, which allowed us to reconstruct and functionally validate the hierarchical organisation of HSC development. The first HSCs emerge in small numbers, possess an enormous regenerative/ self-renewing potential and can generate hundreds of fully functional daughter HSCs. We revealed a highly heterogeneous signalling landscape that can regulate HSC development in a concerted manner. In this talk, commonalities and differences in mouse and human development will be discussed.
