OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
The locus coeruleus (LC), the brain’s principal noradrenergic nucleus, is among the first regions to show tau pathology in Alzheimer’s disease (AD). Its widespread projections regulate arousal, attention, sleep–wake dynamics, often disrupted early in the disease. This seminar will explore recent evidence on the degeneration of the LC across the Alzheimer’s disease continuum, integrating post-mortem, neuroimaging, and cerebrospinal fluid biomarker data. I will discuss how LC dysfunction contributes to cognitive, neuropsychiatric, and sleep alterations in AD, and how targeting this system may open novel diagnostic and therapeutic avenues.
