Oxford Events, the new replacement for OxTalks, will launch on 16th March. From now until the launch of Oxford Events, new events cannot be published or edited on OxTalks while all existing records are migrated to the new platform. The existing OxTalks site will remain available to view during this period.
From 16th, Oxford Events will launch on a new website: events.ox.ac.uk, and event submissions will resume. You will need a Halo login to submit events. Full details are available on the Staff Gateway.
Retrotransposition — the reverse flow of genetic information from RNA to DNA is the major route by which new genetic material enters our genome, with retroelements comprising over 40% of human DNA. This process drives innovation but threatens genome integrity, demanding precise regulation. Our discovery of the Human Silencing Hub (HUSH) revealed a genome-wide transcriptional immunosurveillance system that detects and epigenetically silences invading DNA. How HUSH distinguishes self from invading DNA was unclear. We found that HUSH discriminates ‘self’ from ‘non-self’ based on introns: The majority of cellular genes are intron-containing, while RNA-derived retroelements are intronless, marking their cDNA as foreign. This intron-based recognition mechanism uncovers an unexpected innate immune surveillance system that protects the genome from the reverse flow of genetic information.
