From Models to Mechanisms: Targeting BBB Dysfunction in Neurodegeneration Models

Dr Mootaz Salman (University of Oxford) will explore how innovative organoid and 3-D brain models are advancing our understanding of blood–brain barrier dysfunction in neurodegenerative diseases. By integrating cellular neuroscience, bioengineering, and disease modelling, his work reveals how inflammation- and mechanically-driven changes contribute to barrier breakdown and neuronal decline. This research offers new insights into the mechanisms of neurodegeneration and highlights emerging therapeutic strategies to restore brain health.