OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Inhaled bacille Calmette–Guérin (BCG) provides a controlled human model to interrogate anti-mycobacterial immunity at defined time points, something not feasible in natural Mycobacterium tuberculosis infection. It also represents a promising mucosal vaccination route that outperforms intradermal (ID) BCG in animal models. We will present updated findings from two clinical trials in healthy adults: BCG-naïve and historically BCG-vaccinated participants received aerosolised BCG, with control groups of BCG-naïve participants given inhaled saline and previously vaccinated participants given ID BCG. Lung mucosal and peripheral blood responses were characterised longitudinally using single-cell RNA sequencing (scRNA-seq) and bulk T-cell receptor (TCR) sequencing.
