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Multiple myeloma (MM) is characterized by accumulation of malignant plasma cells in the bone marrow, where tumor cells are in close contact with stromal fibroblasts. Using single cell RNA-sequencing we generated transcriptional maps of MM cells and their stromal and immune microenvironments. This revealed the presence of inflammatory stromal fibroblasts and bone marrow inflammation. I will discuss the identity of the MM stromal cells, their possible impact on MM disease progression and the interactions between inflammatory stromal cells and innate immune cells leading to a pro-tumor bone marrow environment.
