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The ChAHP complex is an essential genome regulator that integrates a transcription factor, a chromatin remodeler and heterochromatin proteins into a single functional unit. I will present our recent discovery of its role in repressing transposons and the molecular mechanisms underpinning this function. Our identification of the paralogous ChAHP2 complex and its distinct properties establishes this protein family as a conserved, vertebrate-specific component of the retrotransposon control machinery.
