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There is evidence from pre-clinical studies that food intake and appetitive gut hormones, including ghrelin and glucagon-like peptide-1 (GLP-1), not only alter appetite, but also food and non-food reward processing, as well as addictive behaviours influencing eating behaviour. There is more limited evidence from human studies. This talk will review our human studies using multi-modal phenotyping, including functional MRI, to study the food-gut-brain axis in eating and addictive behaviours.