Oxford Events, the new replacement for OxTalks, will launch on 16th March. From now until the launch of Oxford Events, new events cannot be published or edited on OxTalks while all existing records are migrated to the new platform. The existing OxTalks site will remain available to view during this period.
From 16th, Oxford Events will launch on a new website: events.ox.ac.uk, and event submissions will resume. You will need a Halo login to submit events. Full details are available on the Staff Gateway.
The exchange of the DNA binding protein RPA for the RAD51 recombinase on single-stranded DNA is a critical step in DNA break repair by homologous recombination. This RPA-RAD51 handoff is dependent on the tumor suppressor BRCA2. Importantly, our work has shown that the BRCA2-associated DSS1, a small, highly acidic protein, is also needed for this handoff process. Mechanistically, DSS1 acts as a DNA mimic to attenuate the affinity of RPA for DNA. Thus, by targeting RPA and mimicking DNA, DSS1 functions with BRCA2 in a two-component homologous recombination mediator complex in genome maintenance.
