OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
The exchange of the DNA binding protein RPA for the RAD51 recombinase on single-stranded DNA is a critical step in DNA break repair by homologous recombination. This RPA-RAD51 handoff is dependent on the tumor suppressor BRCA2. Importantly, our work has shown that the BRCA2-associated DSS1, a small, highly acidic protein, is also needed for this handoff process. Mechanistically, DSS1 acts as a DNA mimic to attenuate the affinity of RPA for DNA. Thus, by targeting RPA and mimicking DNA, DSS1 functions with BRCA2 in a two-component homologous recombination mediator complex in genome maintenance.
