• Type: Seminar Series
• Series organiser: Agata Krupa (Wellcome Trust Centre for Human Genetics)
• Organising department: Wellcome Trust Centre for Human Genetics

Friday 10 April 2015

• 11:00 - Model lipid systems and biophysical approaches for studying protein-membrane interactions
  Dr Gregor Anderluh (National Institute of Chemistry, Slovenia)

Friday 8 May 2015

• 11:00 - A life in pieces: fragments for drug discovery and chemical biology
  Professor Rod Hubbard (University of York)

Friday 12 June 2015

• 11:00 - Cryomicroscopy of cellular and viral architecture
  Prof Peter Rosenthal (The Francis Crick Institute )

Monday 22 June 2015

• 11:00 - The signaling mechanism of a 'double-edged receptor, DCC'
  Dr Jia-Huai Wang (Harvard Medical School )
• 14:00 - Synthetic Virology: A renaissance for structure-function studies
  Benhur Lee (UCLA, School of Medicine)

Friday 10 July 2015

• 11:00 - "Structures and Mechanisms of RNA Polymerase Inhibition by Sigma54"
  Prof Xiaodong Zhang (Imperial College London )

Friday 11 September 2015

• 10:00 - Using Kinematics and modeling to decipher how Toxoplasma parasites apply force to invade host cells
  Dr Isabelle Tardieux ( Institut Cochin, Paris Descartes University)

Friday 9 October 2015

• 11:00 - Assembly and regulation of the DNA damage checkpoint
  Prof Laurence Pearl (University of Sussex)

Friday 13 November 2015

• 11:00 - Recent advances in Cryo-EM structure determination
  Dr Sjors Scheres (MRC Lab of Molecular Biology, Cambridge )

Wednesday 9 December 2015

• 10:30 - Zooming in on cellular and molecular structures with correlative light and electron microscopy
  Prof Bram Koster (Leiden University Medical Center)

Friday 12 February 2016

• 11:00 - "Machinery of drug transport in Escherichia coli and related bacteria"
  Prof Ben Luisi (Department of Biochemistry, University of Cambridge)

Friday 11 March 2016

• 11:00 - Rare events and increasing opportunities: Towards combatting amyloid disease
  Prof Sheena Radford (Astbury Centre for Structural Molecular Biology, University of Leeds)

Friday 8 April 2016

• 11:00 - Membrane pore-forming proteins in the arms race between host and pathogen
  Helen Saibil (Birkbeck College, University of London)

Friday 6 May 2016

• 13:30 - Surface dynamics of ion channels
  Dr. Martin Heine (Leibniz Institute for Neurobiology)

Wednesday 8 June 2016

• 12:00 - Proteus mirabilis copper resistance protein is a shape-shifting redox foldase
  Status: This talk is in preparation - details may change
  Prof Jennifer Martin (The University of Queensland in Australia)

Friday 12 August 2016

• 11:00 - Structural insights into primary microRNA processing
  Dr Jae-Sung Woo (Seoul National University )

Wednesday 31 August 2016

• 11:00 - Visualizing fast 3D dynamics of biological samples using light-sheet microscopy
  Prof Pablo Loza (Institute of Photonic Sciences, Barcelona, Spain)

Friday 9 September 2016

• 15:00 - Mechanisms of Cortical Development: Migration, Circuit Formation and Synaptic Plasticity
  Prof Mary E Hatten (The Rockefeller University )

Friday 16 September 2016

• 11:00 - Structures of Dengue and Zika viruses
  Prof Shee-Mei Lok (Duke-NUS Medical School in Singapore)

Tuesday 10 January 2017

• 14:00 - Beauty and Benefits of cryo-EM; our new endeavors in vitrification of proteins and cells
  Prof Peter Peters (Maastricht University)

Wednesday 25 January 2017

• 13:30 - Integrative 3D imaging: From coral reefs to single cells
  Prof Emmanuel Reynaud (UCD Centre for Biomedical Engineering, Dublin, Ireland)

Friday 3 March 2017

• 11:00 - Protein structure determination to atomic accuracy from cryoEM density using Rosetta
  Prof Frank Dimaio (University of Washington)

Friday 31 March 2017

• 14:15 - "INSIGHTS INTO LIGAND RECOGNITION AND DESENSITIZATION FROM THE X-RAY STRUCTURE OF A NICOTINIC RECEPTOR"
  Asst. Prof Ryan Hibbs (UT Southwestern Medical Center)

Wednesday 29 November 2017

• 12:00 - Structure-assisted Design of Universal Vaccines and Therapeutics against Influenza Virus
  Dr Ian Wilson (The Scripps Research Institute, USA)

Thursday 1 February 2018

• 10:30 - Democratising live-cell high-speed super-resolution microscopy
  Dr Ricardo Henriques (UCL)

Friday 9 March 2018

• 11:00 - Finding new effectors of the bacterial cell cycle by X-ray crystallography
  Prof Rick Lewis (Newcastle University)

Thursday 3 May 2018

• 13:00 - “Visualizing the conformational dynamics of viral membrane fusion machines".
  Asst. Prof James Munro (Tufts School of Medicine, Boston)
• 13:30 - "Mechanical regulation of B cell activation"
  Dr Katelyn Spillane (Department of Physics, King’s College London)

Thursday 10 May 2018

• 11:00 - "Intranuclear Movement of Viruses through the Chromatin Network"
  ADJUNCT PROFESSOR MAIJA VIHINEN-RANTA (University of Jyväskylä in Finland)

Wednesday 16 May 2018

• 15:00 - Inauguration Talk: "An atomic view of biology"
  Prof Jim Naismith (University of Oxford)
• 15:45 - Inauguration Talk: "Structural Mechanisms of Macromolecular Assemblies: from HIV-1 Capsid to Bacterial Chemosensory Arrays"
  Prof Peijun Zhang (University of Oxford)

Friday 18 May 2018

• 11:00 - "An RNA-encoded virus assembly manual: mechanisms and consequences for viral evolution and therapy"
  Prof Reidun Twarock (University of York)

Wednesday 30 May 2018

• 11:00 - "Structure and assembly in the order Picornavirales"
  Dr Shabih Shakeel (MRC LMB in Cambridge)

Thursday 28 June 2018

• 14:00 - "Structural insights into Potato Virus Y - a bad guy and a good guy"
  Assist. Prof Marjetka Podobnik (Department of Molecular Biology and Nanobiotechnology, National Institut of Chemistry, Ljubljana, Slovenia)

Wednesday 19 September 2018

• 10:30 - AURKA KINASE ACTIVITY FRET BIOSENSOR: HCS-FLIM FOR DRUG SCREENING AND OTHER REFINEMENTS
  Dr Marc Tramier (Institute of Genetics & Development Rennes, France)

Friday 21 September 2018

• 11:00 - "Catch me if you can: understanding innate immune evasion by HIV and how to drug it"
  Professor Greg Towers (University College London )

Friday 26 October 2018

• 11:00 - Determining the energy dependence of radiation damage in electron cryo-microscopy of biological specimens
  Dr Christopher Russo (MRC Laboratory of Molecular Biology, Cambridge UK)

Thursday 8 November 2018

• 13:00 - 'Computational methods for carbohydrate structure determination, validation and analysis’
  Dr Jon Agirre (University of York)
• 13:00 - Bioinformatics and CryoEM
  Dr Jon Agirre (University of York)

Friday 18 January 2019

• 11:00 - Probing the mechanism of the SAMHD1 HIV-1 restriction factor
  Dr Ian Taylor (The Francis Crick Institute)

Friday 25 January 2019

• 11:00 - "Cell shape formation controlled by cytoskeleton"
  Dr Naoko Mizuno (Max Planck Institue of Biochemistry)

Thursday 31 January 2019

• 11:00 - "CHEMICAL-GENETIC HYBRID BIOSENSORS FOR FLUORESCENCE MICROSCOPY"
  Dr Alison G. Tebo (Department of Chemistry, École Normale Supérieure, Paris, France)

Monday 25 February 2019

• 11:00 - THE STRUCTURAL BASIS FOR RELEASE FACTOR ACTIVATION DURING TRANSLATION TERMINATION REVEALED BY TIME-RESOLVED CRYOGENIC ELECTRON MICROSCOPY
  Dr Ziao Fu (Columbia University of New York)

Wednesday 8 May 2019

• 11:00 - "From Fragments to Pharmaceuticals"
  Dr Harren Jhoti (Astex Therapeutics Ltd)

Tuesday 14 May 2019

• 11:00 - “Challenges and Opportunities for Automated Cryo Electron Microscopy”
  Adj Prof Bridget Carragher (EM Co-Director at New York Structural Biology Center, Adjunct Professor of Biochemistry and Molecular Biophysics at Columbia University Irving Medical Center)

Friday 5 July 2019

• 11:00 - "Mechanistic and structural insights into protein complexes that regulate DNA repair and mRNA stability"
  Dr Lori Passmore (MRC Laboratory of Molecular Biology in Cambridge)

Wednesday 10 July 2019

• 16:00 - "Portals and DNA packaging in tailed bacteriophages and herpesviruses"
  Prof Miquel Coll ( IRB Barcelona)
• 16:00 - "Portals and DNA packaging in tailed bacteriophages and herpesviruses"
  Prof Miquel Coll ( IRB Barcelona)

Friday 4 October 2019

• 11:00 - From the structure of vertebrate and invertebrate rhodopsins to new applications in optogenetics
  Prof Gebhard F.X. Schertler (Paul Scherrer Institut)

Thursday 17 October 2019

• 11:00 - Dr Ilaria Ferlenghi "An Integrated structural and digital approach for vaccine identification and pathogenesis insight"
  TBA

Friday 18 October 2019

• 11:00 - "Erythrocyte membrane remodelling and destruction by malaria parasites"
  Helen Saibil (Birkbeck College, University of London)

Tuesday 29 October 2019

• 14:00 - "Cryo-EM structure of a poly(A) RNP bound to the Pan2-Pan3 deadenylase"
  Dr Ingmar B Schäfer (Department of Structural Cell Biology, MPI of Biochemistry, Munich, Germany)

Wednesday 15 January 2020

• 11:00 - "Peptides and protons: How pH gradients link transport and trafficking in the cell."
  Professor Simon Newstead (University of Oxford,)

Thursday 6 February 2020

• 11:00 - “Structure-guided steps towards a rational malaria vaccine'"
  Prof Matthew Higgins (University of Oxford)

Wednesday 26 February 2020

• 11:00 - "Membrane Protein Interactions with Lipids as Viewed by Molecular Simulations"
  Prof Mark Sansom (University of Oxford)