• Type: Seminar Series
• Organising department: Department of Oncology

Monday 16 February 2015

• 11:00 - Robustness in biological systems: from DNA replication to cancer
  Prof. Julian Blow

Monday 9 March 2015

• 14:00 - Empowering T cells to combat cancer
  Prof. Aymen A-Shamkhani

Monday 8 June 2015

• 11:00 - The DNA Damage Response
  Dr Kyle Miller (University of Texas at Austin)

Tuesday 23 June 2015

• 13:00 - Oxidation of nucleic acids and control mechanism of spontaneous mutagenesis and tumorigenesis in mammals
  Professor Yusaku Nakebeppu (Medical Institute of Bioregulations, Japan)

Friday 24 July 2015

• 12:15 - Replication fork collapse through ATR inhibition as a cancer treatment
  Dr Eric Brown (University of Pennsylvania)

Monday 27 July 2015

• 11:00 - From Genome Integrity to Genome Plasticity: the Yin-Yang of DNA Replication Control
  Professor Zoi Lygerou (University of Patras, Greece)

Tuesday 1 September 2015

• 11:00 - Basic Mechanisms of Fibrosis and Epigenetic Control
  Professor Derek Mann (Newcastle University Medical School)

Monday 7 September 2015

• 11:00 - Pluripotent stem cells to study neurodegenerative disease and treat neurological disorders
  PD Dr Philipp Koch (Institute of Reconstructive Neurobiology, Life & Brain Center, Sigmund-Freud-Str.25, )

Wednesday 9 September 2015

• 10:00 - Study of the early radiation-induced DNA damage: a computational approach
  Professor Dr Mario Bernal (UNICAMP)

Monday 14 September 2015

• 11:00 - Mechanisms of synergy between ionizing radiation and a therapeutic HPV vaccine
  Professor Eric Deutsch (Gustave Roussy, France)

Monday 26 October 2015

• 11:00 - DNA replication and genome stability: novel molecular insights from a vertebrate cell free system
  Dr Vincenzo Costanzo (IFOM)

Monday 2 November 2015

• 11:00 - Development of AZD5363, an inhibitor of AKT with activity in tumours containing mutations in the P13K-AKT pathway
  Dr Barry Davis ( AstraZeneca)

Monday 16 November 2015

• 11:00 - Maximising anti-tumour immune activation with oncology virotherapy
  Professor Alan Melcher (University of Leeds)

Monday 30 November 2015

• 11:00 - Liver Fibrosis: making sense of inflammation, repair and resolution
  Professor John Iredale (Queen's Medical Research Institute)

Monday 7 December 2015

• 11:00 - The ins and outs of centrosome amplification-mediated invasion
  Dr Susana Godinho (Queen Mary University of London )

Monday 11 January 2016

• 11:00 - Ubiqutin-dependent responses to DNA damage
  Professor Niels Mailand (Protein Signalling Progress, The Novo Nordisk Foundation, Center for Protein Research, University of Copenhagen)

Tuesday 26 January 2016

• 14:00 - Metabolic Imaging using Hyperpolarised 13C Compounds in MRI
  Dr Rolf Schulte (GE Research, Munich )

Monday 8 February 2016

• 11:00 - Mechanisms of DNA Replication Control from Yeast to Human
  Professor Anne Donaldson (University of Aberdeen)

Monday 7 March 2016

• 11:00 - Translating genomic discovery into improved therapies for childhood brain tumours
  Professor Steve Clifford

Friday 8 April 2016

• 12:00 - Radiological Protection - a case of the Emperor's New Clothes
  Prof Wade Allison (University of Oxford)

Monday 9 May 2016

• 11:00 - Translational control visualised in human tumour tissue
  Dr John Le Quesne (Leicester University)

Monday 23 May 2016

• 11:00 - Structural mechanisms of innate immune recognition of cytosolic DNA
  Professor Dr Karl-Peter Hopfner (Ludwig-Maximillians-University of Munich)

Friday 3 June 2016

• 13:00 - Control of cancer cell growth and drug sensitivity by EGFR palmitoylation
  Dr Eric Witze (University of Pennsylvania)

Monday 13 June 2016

• 11:00 - Strategies for radiosensitization with gold nanoparticles
  Sunil Krishnan (Anderson Cancer Centre, Houston)

Monday 27 June 2016

• 11:00 - The study of anti-cancer drug resistance using genetically engineered mouse models for BRCA1/2-mutated breast cancer
  Dr Sven Rottenberg (University of Bern)

Monday 12 September 2016

• 11:00 - Structural insights into LARP1, a significant player in epithelial cancers
  Dr Andrea Berman (Pittsburgh University)

Monday 19 September 2016

• 11:00 - Essential functions of the Zinc-finger transcription factor ASCIZ in DNA damage responses, development and cancer
  Professor Jorg Heierhorst (St Vincents Institute of Medical Research, Austria)

Monday 26 September 2016

• 12:15 - Alternative End joining, the lesser of two evils
  Dr Macel Tijsterman (Leiden University Medical Center)

Monday 10 October 2016

• 11:00 - Title TBC
  Professor Paul Lockhart (Murdoch Childrens Research Institute, Australia)

Monday 7 November 2016

• 11:00 - RNA processing proteins required for DNA replication and the repair of DNA
  Professor Kevin Hiom (Head of Division of Cancer Research, University of Dundee)

Monday 14 November 2016

• 11:00 - Deciphering the role of non-canonical ubiquitination in DNA damage response and DNA replication
  Professor Lorenza Penengo (Institute of Molecular Cancer Research, University of Zurich)

Monday 28 November 2016

• 11:00 - Early diagnosis of Pancreatic cancer using a simple blood sample
  Professor Carl Borrebaeck (Department of Immunotechnology, Lund University, Sweden)

Monday 5 December 2016

• 11:00 - The radiobology of proton beam therapy: Associateds with DNA damage complexity and ubiquitin-dependent responses
  Dr J L Parsons (University of Liverpool)

Monday 12 December 2016

• 11:00 - A novel mechanism for controlling the bioavailability and activation of latent TGFb
  Tonia Vincent (University of Oxford)

Monday 16 January 2017

• 11:00 - PET for radiation treatment planning and monitoring
  Professor Anca-Ligia Grosu (Department of Radiation Oncology, University Medical Center, Freiburg)

Monday 23 January 2017

• 11:00 - From Chernobyl to Fukushima: environmental consequences of nuclear accidents
  Professor J T Smith (School of Earth & Environmental Sciences, University of Portsmouth)

Thursday 26 January 2017

• 13:00 - DNA supercoiling, SMC complexes and chromosome segregation
  Professor Camilla Sjögren (Professor in Cell and Tumour Biology, Department of Cell and Molecular Biology, Karolinska Institute, Stockholm)

Friday 27 January 2017

• 13:45 - Success in science: promoting the next generation
  Professor Louise Richardson (University of Oxford), Dame Jocelyn Bell Burnell (University of Oxford), Camilla Sjogren (Karolinska Institute), Andrew Blackford (University of Oxford), Ngee Han Lim (University of Oxford)

Friday 10 February 2017

• 12:00 - The toxicity of polonium-210 and its use by Russian agents to poison Alexander Litvinenko
  Dr John Harrison (Public Health England)

Friday 24 February 2017

• 11:30 - The Cancer Cell Map Initiative : Using Network Biology to Interpret Cancer Genomic Data
  Professor Nevan Krogan (University of California)

Monday 27 February 2017

• 11:00 - Controlling nucleases that determine our genetic make-up
  Joao Matos (PhD, Assistant Professor of Cellular Biochemistry, Institute of Biochemistry, ETH Zurich)

Monday 13 March 2017

• 11:00 - STAT Transcription Factors in the Pathogenesis and Treatment of Cancer
  David A. Frank, MD, PhD (Associate Professor of Medicine, )

Monday 20 March 2017

• 11:00 - Bouncers of the chromatin: Ubiquitin and SUMO tell when it is time to leave
  Professor Nico Dantuma (Professor of Molecular Cell Biology, Karolinska Institute, Sweden)

Monday 27 March 2017

• 11:00 - The p53 family in cancer biology
  Professor Gerry Melino (Head of 'Apoptosis & Cancer' Section, MRC Toxicology Unit, University of Leicester)

Monday 15 May 2017

• 11:00 - An integrated ATR, ATM and mTOR-mechanical network controlling nuclear plasticity and cell migration
  Marco Foiani (Professor of Molecular Biology, Department of Biosciences, University of Milan)

Monday 22 May 2017

• 11:00 - Regulation of genome maintenance throughout the cell cycle
  Marcel A.T.M van Vugt PhD (Department of Medical Oncology,)

Wednesday 24 May 2017

• 13:30 - Early Observations on the Use of EGFRvIII-directed CART cells for Human Glioblastoma: Clinical Results and Future Directions
  Donald M. O’Rourke, M.D (Department of Neurosurgery, University of Pennsylvania School of Medicine, The Abramson Cancer Center, Philadelphia)

Monday 19 June 2017

• 11:00 - Using planarian flatworms as a model system for stem cells, regeneration and cancer
  Aziz Aboobaker (Department of Zoology, University of Oxford)

Thursday 6 July 2017

• 11:00 - NON-KINASE TARGETS OF PROTEIN KINASE INHIBITORS
  Associate Professor Lenka Munoz (University of Sydney, Australia)

Monday 17 July 2017

• 11:00 - The Nucleolar Response to Chromosome Breaks
  Manuel Stucki PhD, Dept. of Gynecology (University of Zurich)

Monday 18 September 2017

• 11:00 - Mechanisms regulating cellular plasticity underlying the initiation, progression and therapeutic resistance of pancreas adenocarcinoma
  Professor Rosalie Sears (Knight Cancer Institute)

Monday 2 October 2017

• 11:00 - Defining novel subsets of hereditary renal cancer with defects in DNA replication and repair pathways
  Sanjeevani Arora PhD (Fox Chase Cancer Centre)

Wednesday 4 October 2017

• 13:30 - CRUK Oxford Centre - Oesophageal Working Group
  Dr John Findlay (Department of Oncology), Mr Stephen Ash (Ludwig), Dr Ling Yang (Ludwig)

Monday 9 October 2017

• 11:00 - PET for Radiation Treatment Planning and Monitoring
  Professor Anca-Ligia Grosu (Department of Radiation Oncology University Medical )

Monday 23 October 2017

• 11:00 - CHD6 is a novel oxidative DNA damage response factor
  Dr Aaron Goodarzi (Arnie Charbonneau Cancer Institute)

Wednesday 1 November 2017

• 12:00 - Polyadenylation as a therapeutic target in cancer
  Cornelia H. de Moor, PhD (Faculty of Science, Nottingham University)

Monday 6 November 2017

• 11:00 - Schizophrenic DNA repair: establishment and instability of a RNA/DNA hybrid genome
  Giovanni Maga PhD (Institute of Molecular Genetics IGM-CNR, National Research Council, Italy)

Monday 4 December 2017

• 11:00 - Novel DNA nuclease function governs cell fate decisions in response to ionizing radiation
  Claus Storgaard Sørensen Ph.D. (Biotech Research & Innovation Centre (BRIC))

Monday 11 December 2017

• 11:00 - Roles and regulation of the eukaryotic replisome
  Professor Karim Labib (University of Dundee)

Thursday 14 December 2017

• 13:00 - Biochemical reconstitution of the Fanconi Anaemia pathway
  Dr Andrew Deans (Head of Genome Stability Unit, St Vincent’s Institute for Medical Research, Melbourne, Australia)

Monday 18 December 2017

• 11:00 - Regulation of Wnt/β-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding
  Sebastian Guettler PhD (The Institute of Cancer Research, London)

Monday 22 January 2018

• 11:00 - Function and execution of RTEL1 activities at vertebrate telomeres
  Simon Boulton PhD FMedSci (The Francis Crick Institute)

Monday 29 January 2018

• 11:00 - Exploiting Cancer’s Addiction to Deregulated G1/S Transcription
  Professor Rob De Bruin (UCL Professor of Molecular Biology)

Wednesday 28 February 2018

• 11:30 - Distance effects on double strand break repair efficiency and accuracy: the double life of RAD51, and consequences on genome stability in mammalian cells
  Professor Bernard Lopez (Institute Gustave Roussy, Paris)

Monday 5 March 2018

• 11:00 - The interplay between nuclear, mitochondrial DNA repair and autophagy
  Professor Sherif El-Khamisy, Professor of Molecular Medicine (University of Sheffield)

Friday 9 March 2018

• 13:00 - Mechanisms of oncogene-induced DNA replication stress
  Professor Thanos Halazonetis (University of Geneva)

Monday 12 March 2018

• 11:00 - Advancing Precision Oncology by Computational Modelling
  Professor Walter Kolch (University College Dublin)

Monday 19 March 2018

• 11:00 - Functional DNA repair testing for cancer risk assessment, prevention and early detection: Lung Cancer and more
  Professor Zvi Livneh (Department of Biomolecular Sciences, Weizmann Institute of Science, Israel)

Monday 26 March 2018

• 11:00 - CRL4 ubiquitin ligase regulates the response to UV- and cisplatin-DNA damage
  Professor Hanspeter Naegeli (University of Zurich)

Monday 16 April 2018

• 11:00 - The role of ATRX during DNA double-strand break repair
  Professor Markus Löbrich (Technical University Darmstadt Biology, Department of Biology)

Monday 30 April 2018

• 11:00 - Old and new functions of BRCA1
  Professor Jo Morris PhD MSc (Institute of Molecular Medicine, University of Sheffield)

Monday 14 May 2018

• 11:00 - Allosteric regulation of RING E3 ligases
  Professor Helen Walden (University of Glasgow)

Monday 4 June 2018

• 11:00 - Unusual DNA/RNA structures in health and disease
  Natalia Gromak, PhD (University of Oxford)

Monday 18 June 2018

• 11:00 - Stres-Induced Dynamic Regulation of Mitochondrial STAT3 and Its Association with Cyclophilin D
  Professor Andrew Larner (Virginia Commonwealth University)

Monday 25 June 2018

• 11:00 - Roles and Regulation of the eukaryotic replisome
  Professor Karim Labib (University of Dundee)

Monday 17 September 2018

• 11:00 - Title TBC
  Sabine Tejpar (KU LEUVEN, Molecular Digestive Oncology)

Friday 12 October 2018

• 08:00 - The International Marie Sklodowska-Curie Meeting: From Radiation to Innovation in Medicine - Venue Institut Curie, Paris
  Various Speakers

Monday 22 October 2018

• 11:00 - Disassembly of replication machinery at termination of DNA replication forks
  Dr Agnieszka Gambus (University of Birmingham)

Monday 29 October 2018

• 11:00 - The role of ATRX in repairing internal and telomeric DNA double-strand breaks
  Professor Markus Löbrich (Technical University Darmstadt Biology)

Monday 5 November 2018

• 12:00 - FAN1: a Fanconi anaemia (FA) protein but not a FA gene
  Professor Josef Jiricny (Institute of Biochemistry (ETH))

Monday 12 November 2018

• 11:00 - Fidelity of DNA double strand break repair is embedded in 3D structure of the neighboring chromatin
  Dr Fena Ochs (University of Copenhagen)

Monday 19 November 2018

• 11:00 - Developing T cell receptor therapies to target cancer
  Marco Lepore (Immunocore), David Cole (Immunocore)

Monday 10 December 2018

• 11:00 - Epigenome maintenance in response to DNA damage
  Sophie Polo, PhD (Universitè Paris Diderot, Epigenetics and Cell Fate Centre)

Monday 28 January 2019

• 11:00 - Publishing and Careers at Nature Research
  Dr Anne Mirabella (Nature Communications)

Monday 11 February 2019

• 11:00 - Regulation of ribosome biogenesis by RNA localisation
  Faraz Mardakheh (University of London)

Monday 18 February 2019

• 11:00 - Mechanisms linking DNA replication to cell fate determination under normal and stressful conditions
  Dr Vincenzo Costanzo (IFOM)

Monday 4 March 2019

• 11:00 - The FANC (Fanconi anemia) pathway: far beyond the protection of DNA replication
  Filippo Rosselli (Institut Gustave Roussy)

Monday 11 March 2019

• 11:00 - Blocking DNA replication before it starts: insights on CDC7 kinase inhibition by chemical genetics and genome editing approaches
  cancelled and will be rescheduled for later in the year
  Prof Corrado Santocanale (National University of Ireland Galway)

Monday 18 March 2019

• 11:00 - Topoisomerase II acts on SMC complex dependent DNA topological stress during both S phase and M phase
  Dr Jon Baxter (University of Sussex)

Tuesday 16 April 2019

• 12:00 - The Triple Win: how the UK can achieve personalised medicine, a growing life science sector, and an affordable NHS
  Lord James O'Shaughnessy

Monday 13 May 2019

• 11:00 - Homologous recombination DNA repair is the major driver of PARPi sensitivity in breast cancer
  Violeta Serra (Vall d'Hebrón Institut d’Oncologia)

Thursday 13 June 2019

• 11:00 - Ubiquitin, signaling in normal and cancer cell cycles
  Michael J. Emanuele (UNC School Medicine, University of Virginia)

Monday 24 June 2019

• 11:00 - Taking apart the nuclear envelope for open mitosis
  Prof. Dr. Ulrike Kutay

Monday 8 July 2019

• 11:00 - Impaired ribosome biogenesis and diseases
  Prof Sinisa Volarevic (Medical School, University of Rijeka, Croatia)

Friday 12 July 2019

• 11:00 - Radiotherapy as Immunotherapy
  Professor Alan Melcher (Translational Immunology, The Institute of Cancer Research)

Thursday 25 July 2019

• 12:00 - Degrading activities: Regulation of cellular biology by the ubiquitous pathway
  Professor David P. Toczyski (University of California San Francisco)

Monday 2 September 2019

• 11:00 - Reducing tumor hypoxia with mitochondrial inhibitors, translation to clinical studies
  Professor Nicolas Denko (The Ohio State University Wexner Medical Center)

Friday 20 September 2019

• 11:00 - Developing Affinity-Based Therapies for Targeting Metastatic Cancers
  Dr. Yu Rebecca Miao (Dept. Radiation Oncology, Stanford University )

Monday 7 October 2019

• 14:00 - Clinical relevance of hyper-recombination in cancer
  Dr. Anand Jeyasekharan (Consultant, Department of Haematology-Oncology, National University Hospital Singapore, and PI at the Cancer Science Institute, National University of Singapore)

Monday 25 November 2019

• 11:00 - Therapy Resistance – Cancer Stem Cells and 3D Models of the Breast Cancer Microenvironment
  Gillian Farnie (University of Oxford NDORMS)

Wednesday 27 November 2019

• 12:00 - Characterizing both neoantigen and microenvironment of colorectal cancer for precision immunotherapy
  Professor Jimin Shao (Zhejiang University )