Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease characterized by the loss of dopaminergic neurons in the midbrain. Despite intensive research over the last decades, our understanding of the complex disease progression is still rather limited. The talk will show how we use longitudianal multiomics characterization of patient-based induced pluripotent stem cells to identify underlying mechanisms of PD development in a top-down approach, and how the identified core mechanism of calcium-mediated mitochondrial control can be mechanistically investigated by combining experiments with computational modelling in an integrative bottom-up approach.