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This talk presents results from the Million Women Study, a large 20-year prospective cohort. The talk will first explain the methods of the Study and briefly summarise some of the many results arising from the Study. A rationale will be presented for why the cohort is a useful resource for investigating risk factors for dementia. Results will then be presented from an analysis aimed at determining whether mid-life obesity, poor diet and physical inactivity are causes of dementia.