• Type: Seminar Series
• Series organisers: Fiona Lambert (University of Oxford, MRC Weatherall Institute of Medicine) , Emma Butterfield (MRC Weatherall Institute of Molecular Medicine) , Beatriz Hirt-Font (University of Oxford, MRC Weatherall Institute of Molecular Medicine)
• Timing: Tuesdays at 1.00 pm
• Organising department: MRC Molecular Haematology Unit

Tuesday 17 February 2015

• 13:00 - Loss of DNA methylation drives Polycomb redistribution
  Dr. Sarah Cooper (Dept of Biochemistry, University of Oxford)

Tuesday 24 February 2015

• 13:00 - Transcriptional regulation of the quiescent human haematopoietic stem cell pool
  Dr. Elisa Laurenti (WT-MRC Cambridge Stem Cell Institute, Cambridge)

Tuesday 3 March 2015

• 13:00 - MHU Student Presentations
  Helen Doolittle, Joanna Green, Laura Stenson

Tuesday 17 March 2015

• 13:00 - FoldSynth: A physics-based interactive visualisation platform for proteins and other molecular strands
  Prof Frederic Fol Leymarie (Goldsmiths, University of London), Stephen Todd (Goldsmiths, University of London)

Tuesday 24 March 2015

• 13:00 - MHU Student Presentations
  Aimee Fenwick, Jon Kerry, Marta Tapia

Tuesday 21 April 2015

• 13:00 - MHU Student Presentations
  Florian Bonkhofer, Laura Godfrey, Lucas Greder

Tuesday 28 April 2015

• 13:00 - Population and Rare Diseases Genomics: Any lessons learned about megakaryopoiesis and platelet formation?
  Prof Willem Ouwehand (Professor of Experimental Haematology University of Cambridge & Wellcome Trust Sanger Institute and NHS Blood and Transplant)

Tuesday 5 May 2015

• 13:00 - Preferentially targeting Jak2-mutant cells in myeloproliferative neoplasms (MPN)
  Ann Mullally (Harvard Medical School, USA)

Tuesday 12 May 2015

• 13:00 - MHU Student Presentations
  Akiko Hashimoto, Anthony Cheong, Christopher Booth

Tuesday 19 May 2015

• 13:00 - How does the embryo make haematopoetic stem cells?
  Prof Alexander Medvinsky (Institute for Stem Cell Research, Edinburgh)

Tuesday 26 May 2015

• 13:00 - Regulation of bone morphogenesis by vascular niche
  Dr. Anjali Kusumbe (Max Planck Institute for Molecular Biomedicine, Munster, Germany)

Tuesday 9 June 2015

• 13:00 - Floor meeting - 2 groups will give an update on the research work in their laboratory
  Dr Petter Woll (University of Oxford, Weatherall Institute of Molecular Medicine), Dr Kerol Bartolovic (University of Oxford, Weatherall Institute of Molecular Medicine)

Tuesday 23 June 2015

• 13:00 - How to build the largest functional domain in the human nucleus
  Professor Brian McStay (Centre for Chromosome Biology, National University of Ireland, Galway)

Tuesday 6 October 2015

• 13:00 - Title TBC
  Dr Ben Goldacre (Dept of Primary Care Health Sciences, University of Oxford)

Tuesday 13 October 2015

• 13:00 - Dynamic phosphorylation patterns of RNA polymerase II CTD during transcription
  Prof Dr Dirk Eick (Dept of Molecular Epigenetics, Helmholtz-Zentrum, Muenchen, Germany)

Tuesday 27 October 2015

• 13:00 - Floor meeting - 2 groups will give an update on the research work in their laboratory
  Dr Bryony Graham (MRC Molecular Haematology Unit, WIMM), Dr Neo Wen Hao (MRC Molecular Haematology Unit, WIMM)

Tuesday 3 November 2015

• 13:00 - Chromatin repllication and epigenome maintenance
  Dr Anja Groth (Biotech Research & Innovation Centre, University of Copenhagen, Denmark)

Tuesday 17 November 2015

• 13:00 - Floor meeting - 2 groups will give an update on the research work in their laboratory
  Dr Dimitris Karamitros (MRC Molecular Haematology Unit, WIMM), Dr Diu Nguyen (MRC Molecular Haematology Unit, WIMM)

Tuesday 24 November 2015

• 13:00 - Cohesin proteins bridge genome topology and function
  Dr Suzana Hadjur (University College London)

Tuesday 1 December 2015

• 13:00 - Floor meeting - 2 groups will give an update on the research work in their laboratory
  TBA

Tuesday 19 January 2016

• 13:00 - Mechanisms and function of parental specific heterochromatin in mouse early embryos
  Prof Dr Antoine Peters (Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland)

Tuesday 8 March 2016

• 13:00 - MHU Student Presentations
  Anthony Cheong; Jennifer Chambers; Lucas Greder

Tuesday 15 March 2016

• 13:00 - Chaperones turned oncoproteins: calreticulin mutants pathologically activate TpoR and the JAK-STAT pathway in myeloid cancers
  Prof Stefan Constantinescu (Head, Signal Transduction & Molecular Hematology Unit, Ludwig Institute for Cancer Research, Brussels, Belgium)

Tuesday 22 March 2016

• 13:00 - Cooperative and dynamic organisation of DNA regulatory elements
  Dr Guillaume Orsi (Institut Curie - Centre de Recherche, Paris, France)

Tuesday 12 April 2016

• 13:00 - Haematopoietic flow, cell competition and T cell acute lymphoblastic leukaemia
  Professor Hans-Reimer Rodewald (German Cancer Research Center)

Tuesday 19 April 2016

• 13:00 - MHU Student Presentations
  Julia Truch; Martin Larke; Eleni Louka

Tuesday 26 April 2016

• 13:00 - Single cell gene expression dynamics
  Professor Jonathan Chubb (MR Laboratory for Molecular Cell Biology, University College London)

Tuesday 3 May 2016

• 13:00 - Haematopoietic stem cells in development and disease
  Dr Katrin Ottersbach (MR Centre for Regenerative Medicine, University of Edinburgh)

Tuesday 24 May 2016

• 13:00 - Single-cell analysis of Blimp1+ cell types at the maternal-foetal interface
  Dr Andrew Nelson (Sir William Dunn School of Pathology, University of Oxford)

Tuesday 31 May 2016

• 13:00 - MHU Student Presentations
  Cristina di Genua; Florian Bonkhofer; Alexander Thomas

Tuesday 7 June 2016

• 13:00 - Insights into inherited susceptibility to B-cell malignancies
  Professor Richard Houlston (Institute of Cancer Research, London)

Tuesday 14 June 2016

• 13:00 - Novel mechanisms and therapies in acute myeloid leukaemia
  Professor Tim Somervaille (Institute of Cancer Sciences, University of Manchester)

Tuesday 21 June 2016

• 13:00 - The first human immortalised cell line generated from adult erythroid cells
  Dr Jan Frayne (School of Biochemistry, University of Bristol)

Tuesday 28 June 2016

• 13:00 - MHU Student Presentations
  Juan Pablo Ruiz; Zahra Aboukhalil; Marieke Oudelaar

Tuesday 12 July 2016

• 13:00 - Clinical and molecular studies of congenital dyserythropoietic anaemia type 1
  Professor Hannah Tamary (Schneider Children's Medical Center of Israel)

Tuesday 26 July 2016

• 13:00 - Cellular and gene therapy for erythroid disorders: opportunities and challenges
  Dr Raffaele Renella (Hemato-Oncologue Pediatre FMH, Lausanne, Switzerland)

Tuesday 4 October 2016

• 13:00 - Introducing GSK Discovery Partnerships with Academia - Innovative Medicines from integrated industry-academia partnerships
  Dr Andrew Pearce (GSK Medicines Research Centre, Stevenage)

Tuesday 18 October 2016

• 13:00 - Eavesdropping on embryonic development with multimodal imaging
  Dr Scott Fraser (University of Southern California, Los Angeles, USA)

Tuesday 25 October 2016

• 13:00 - Single cell analysis of the bone marrow niche identifies novel regulators of haematopoietic regeneration
  Dr Lev Silberstein (Dept of Molecular & Cellular Biology, Harvard University, USA)

Tuesday 8 November 2016

• 13:00 - DNMT3A in normal and malignant haematopoiesis
  Dr Margaret Goodell (Stem Cells & Regenerative Medicine Center, Baylor College of Medicine, Houston, USA)

Tuesday 15 November 2016

• 13:00 - What is the reproducibility crisis in science and what can we do about it?
  Professor Dorothy Bishop (Dept of Experimental Psychology, University of Oxford)

Tuesday 22 November 2016

• 13:00 - Use of single cell transcriptomics to study blood stem cells formation
  Dr Christophe Lancrin (EMBL Monterotondo Mouse Biology Unit, Monterotondo, Italy)

Tuesday 29 November 2016

• 13:00 - Stem cell dynamics in homeostasis and cancer
  Dr Edward Morrissey (MRC WIMM, University of Oxford)

Tuesday 6 December 2016

• 13:00 - Exploring the role of SCF at the onset of haematopoiesis
  POSTPONED TO THE NEW YEAR
  Emanuele Azzoni (MRC MHU, MRC Weatherall Institute of Molecular Medicine, University of Oxford)

Tuesday 17 January 2017

• 13:00 - AML genetics, forward and reverse
  Dr George Vassiliou (Wellcome Trust Sanger Institute, Cambridge)

Tuesday 31 January 2017

• 13:00 - How replication impediments impair epigenetic memory
  Dr. Julian Sale (MRC Laboratory of Molecular Biology, University of Cambridge)

Tuesday 21 February 2017

• 13:00 - MHU Student Presentations
  Yavor Bozhilov; Laura Godfrey; Andrew King (MRC WIMM, University of Oxford)

Tuesday 28 February 2017

• 13:00 - A view of haematopoietic development and disease from the Petri dish
  Dr. Andrea Ditadi (San Raffaelle Scientific Institute, Milan)

Tuesday 7 March 2017

• 13:30 - Congenital dyserythropoietic anaemias: from clilnical manifestations to molecular pathogenesis
  Achille Iolascon (Dept of Molecular Medicine & Medical Biotechnology, University of Naples, Italy)

Tuesday 28 March 2017

• 13:00 - Computational approaches to gene expression and regulation in blood cells and cancer
  Professor David Westhead (Head of the School of Molecular and Cellular Biology, University of Leeds)

Tuesday 4 April 2017

• 13:00 - Evolution of tissue-specific enhancers across mammals
  Dr Duncan Odom (CRUK Cambridge Institute & WT Sanger Institute, Cambridge)

Tuesday 25 April 2017

• 13:00 - MHU Student Presentations
  Tomasz Dobrzycki; Akiko Hashimoto; Dominic Owens (MRC WIMM, University of Oxford)

Tuesday 2 May 2017

• 13:00 - Dysregulated haematopoiesis in chronic inflammatory diseases
  Dr. Thibault Griseri (Kennedy Institute of Rheumatology, University of Oxford)

Tuesday 9 May 2017

• 13:00 - Aberrant chromatin programming in Acute Myeloid Leukaemia
  Professor Constanze Bonifer (Institute for Cancer & Genomic Sciences, University of Birmingham)

Tuesday 23 May 2017

• 13:00 - MHU Student Presentations
  Hannah Ralph; Helen Doolittle; Helena Francis (MRC WIMM, University of Oxford)

Tuesday 30 May 2017

• 13:00 - Towards the understanding of molecular mechanisms of epigenetic reporgramming in vivo
  Dr. Petra Hajkova (MRC Institute of Medical Sciences, London)

Tuesday 6 June 2017

• 13:00 - MRC Translational Activities and Opportunities
  Dr. Alex Pemberton (Medical Research Council, London)

Tuesday 13 June 2017

• 13:00 - GATA2 zinc finger interactions with DNA and FOG1 are structurally encoded
  Dr Sarah Nurmohamed (Division of Structure Biology, University of Oxford)

Tuesday 27 June 2017

• 13:00 - MHU Student Presentations
  Akiko Hashimoto; Michael Weinberger, Catherine Garnett, Carolline Telfer (MRC WIMM, University of Oxford)

Tuesday 11 July 2017

• 13:00 - MHU Student Presentations
  Christopher Booth; Alba Rodriguez Meira, Caroline Harrold (MRC WIMM, University of Oxford)

Tuesday 5 September 2017

• 13:00 - Metabolism, control of cell fate decisions, and stem cell renewal
  Dr Keisuke Ito (Albert Einstein College of Medicine)

Tuesday 12 September 2017

• 13:00 - Dynamic remodelling of the haematopoietic stem cell niche
  Dr Owen Tamplin (Dept of Pharmacology, University of Illinois at Chicago, USA)

Tuesday 19 September 2017

• 13:00 - Development, maintenance and function of tissue resident macrophages
  Dr Elisa Gomez Perdiguero (Institut Pasteur, Paris, France)

Tuesday 26 September 2017

• 13:00 - Mechanotransduction in physiology and cardiovascular disease
  Professor Ellie Tzima (Radcliffe Department of Medicine, University of Oxford)

Tuesday 3 October 2017

• 13:00 - Understanding regulatory variation in humans through variable chromatin modules
  Dr Bart Deplancke (Swiss Federal Institute of Technology, Lausanne, Switzerland)

Tuesday 17 October 2017

• 13:00 - Floor meeting - 2 groups will give an update on the research work in their laboratory
  Various Speakers

Tuesday 24 October 2017

• 13:00 - The emergence of erythropoiesis from the early haematopoietic hierarchy: a single cell-RNA-seq approach
  Assoc Prof Merav Socolovsky (University of Massachusetts Medical School, USA)

Tuesday 31 October 2017

• 13:00 - Exploring the mechanisms of haematopoietic lineage progression at the single-cell level
  Professor Ana Cvejic (WT-MRC Cambridge Stem Cell Institute)

Tuesday 7 November 2017

• 13:00 - Floor meeting - 2 groups will give an update on the research work in their laboratory
  Various Speakers

Tuesday 14 November 2017

• 13:00 - Visualisation in biology: much more than pretty pictures
  Dr. Monica Zoppe (Institute of Clinical Physiology-CNR, Pisa, Italy)

Tuesday 21 November 2017

• 13:00 - Forward programming and gene editing: the tools for making blood cells with added clinical benefit
  Dr Cedric Ghevaert (Cambridge Blood Centre, Cambridge)

Tuesday 28 November 2017

• 13:00 - Mechanisms behind mammalian early embryogenesis in vitro and in vivo
  SEMINAR POSTPONED TO THE NEW YEAR DUE TO ILLNESS
  Prof Magdalena Zernicka-Goetz (Mammalian Embryo & Stem Cell Group, University of Cambridge)

Tuesday 5 December 2017

• 13:00 - DNA methylation of transcribed CpG islands depends on their transcriptional activity during differentiation and disease
  Dr. Danuta Jeziorska (MRC Molecular Haematology Unit, University of Oxford)

Tuesday 6 February 2018

• 13:00 - Targeting splicing in myeloid neoplasms - from bench to bedside
  Professor David Steensma (Dana-Farber Cancer Institute, Boston, USA)

Tuesday 13 February 2018

• 13:00 - Student presentations
  Various Speakers

Tuesday 20 February 2018

• 13:00 - How chromatin organises in mammalian cells - lessons from 3D super-resolution microscopy
  Dr. Lothar Schermelleh (Dept of Biochemistry, University of Oxford)

Tuesday 27 February 2018

• 13:00 - Enhancers of Sonic hedgehog gene expression and making long distance relationships work
  Professor Robert Hill (MRC Institute of Genetics & Molecular Medicine, University of Edinburgh)

Tuesday 6 March 2018

• 13:00 - Gene therapy for hemoglobinopathies: where we are and future perspectives
  Professor Giuliana Ferrari (San Raffaele Telethon Institute for Gene Therapy, Milan, Italy)

Tuesday 13 March 2018

• 13:00 - Student presentations
  Various Speakers

Tuesday 20 March 2018

• 13:00 - How do gene families evolve?
  Ed Tunnacliffe (MRC Laboratory for Molecular Cell Biology, University College London)

Tuesday 24 April 2018

• 12:45 - Student presentations
  Please note earlier start time for these presentations
  Various Speakers

Tuesday 15 May 2018

• 12:45 - Student presentations
  Please note earlier start time for these presentations
  Various Speakers

Tuesday 22 May 2018

• 13:00 - Charting the cellular and molecular journey of single stem cells in ageing and cancer
  Dr David Kent (Wellcome/MRC Cambridge Stem Cell Institute)

Tuesday 29 May 2018

• 13:00 - Novel metabolic regulators of haematopoietic stem cell biology and leukaemic transformation
  
  Kamil Kranc (MRC Centre for Regenerative Medicine, University of Edinburgh )

Tuesday 5 June 2018

• 13:00 - Asynchronous T and B lineage priming condition commitment in fetal hematopoietic progenitors
  Professor Ana Cumano (Institut Pasteur, France)

Tuesday 12 June 2018

• 13:00 - Targeting autophagy and metabolic dependencies in leukaemic stem cells
  Vignir Helgason (Wolfson Wohl Cancer Research Centre, University of Glasgow)

Tuesday 19 June 2018

• 13:00 - Using single-cell technologies and planarians to study stem cells, their differentiation and their evolution
  Jordi Solana (Dept of Biological & Medical Sciences, Oxford Brookes University)

Tuesday 26 June 2018

• 13:00 - Controlling mouse HSC function and myelopoiesis in vivo
  Claudia Waskow (TU Dresden, Germany)

Tuesday 18 September 2018

• 13:00 - Employing CRISPR to understand neurodegenerative disease in human induced pluripotent stem cells
  Dr Andrew Bassett (Wellcome Trust Sanger Institute)

Tuesday 23 October 2018

• 13:00 - Discovery of cellular and molecular targets to extend hematopoietic healthspan
  Dr Jennifer Trowbridge (The Jackson Laboratory, Bar Harbor, USA)

Tuesday 13 November 2018

• 13:00 - Floor meeting - 2 groups will give an update on the research work in their laboratory
  TBA

Tuesday 20 November 2018

• 13:00 - Balancing cell potency and specification in stem cells and in the early embryo
  Dr Veronique Azuara (Institute of Reproductive & Developmental Biology, Imperial College London Faculty of Medicine)

Tuesday 27 November 2018

• 13:00 - Floor meeting - 2 groups will give an update on the research work in their laboratory
  TBA

Tuesday 4 December 2018

• 13:00 - Understanding early mouse and human development
  Dr Magdalana Zernicka-Goetz (University of Cambridge)

Tuesday 11 December 2018

• 13:00 - From the immune system to cancer: 53BP1 cooperation with the Rev7-Shieldin complex underpins DNA structure-specific non-homologous end joining
  Dr Ross Chapman (Head of Genome Integrity Laboratory, Wellcome Centre for Human Genetics, Oxford)

Tuesday 15 January 2019

• 13:00 - MHU Student Presentations
  Various Speakers

Tuesday 22 January 2019

• 13:00 - The human centromere, a paradigm in chromatin-based epigenetic inheritance
  Dr Lars Jansen (Dept of Biochemistry, University of Oxford)

Tuesday 19 February 2019

• 13:00 - Stem cells and differentiation in myelodysplastic syndromes
  Professor Eva Hellstrom Lindberg (Dept of Medicine, Karolinska Institute, Sweden)

Tuesday 26 February 2019

• 13:00 - Spatial In Vivo Transcription Profiling with Single-Molecule Imaging
  Dr Antti Lignell (Faculty of Medicine, University of Helsinki, Finland)

Tuesday 5 March 2019

• 13:00 - Title TBC
  Dr Benjamin Fairfax (Molecular Oncology, MRC WIMM)

Tuesday 12 March 2019

• 13:00 - Regulation of dormant hematopoietic stem cells
  Dr Nina Cabezas-Wallscheid (Max-Planck-Institute of Immunobiology and Epigenetics)

Tuesday 19 March 2019

• 13:00 - Exploring the role of RNA modifications in myeloid leukaemogenesis
  Dr Konstantinos Tzelepis (WT-CRUK Gurdon Institute, Cambridge)

Tuesday 26 March 2019

• 13:00 - MHU Student Presentations
  Various Speakers

Tuesday 2 April 2019

• 13:00 - Repression of gene expression by Groucho/TLE family proteins during development and disease
  Dr Barbara Jennings (Dept of Biological & Medical Sciences, Oxford Brookes University)

Tuesday 23 April 2019

• 13:00 - Functional dissection of the 3D genome
  Elzo de Wit (The Netherlands Cancer Institute, Amsterdam, The Netherlands)

Tuesday 30 April 2019

• 13:00 - MHU Student Presentations
  Various Speakers

Tuesday 7 May 2019

• 13:00 - Rewriting the mammalian cell ’source code’
  Professor Tudor Fulga (MRC WIMM, University of Oxford)

Tuesday 14 May 2019

• 13:00 - Asymmetric stem cell division to tissue engineering
  Dr Shukry Habib (Centre for Stem Cells & Regenerative Medicine, King's College London)

Tuesday 21 May 2019

• 13:00 - Genetic determinants of context specific gene expression and DNA methylation in primary human monocytes
  Dr Benjamin Fairfax (Dept of Oncology, WIMM)

Tuesday 28 May 2019

• 13:00 - Surveying structural variation landscapes in single cells by strand-specific sequencing reveals complex genomic rearrangements in T-ALL
  Dr Ashley Sanders (Genome Biology Unit, EMBL, Heidelberg)

Tuesday 4 June 2019

• 13:00 - MHU Student Presentations
  Various Speakers

Tuesday 2 July 2019

• 13:00 - Genetic engineering of human hematopoiesis for treating inherited diseases and cancer
  SEMINAR CANCELLED DUE TO ILLNESS OF SPEAKER
  Dr Luigi Naldini (San Raffaele Telethon Institute for Gene Therapy, Milan, Italy)

Tuesday 9 July 2019

• 12:30 - Applying precision medicine to a third world country: an experience from Thailand
  Please note earlier start time of 12.30 pm
  Professor Vip Viprakasit (Professor of Paediatrics, Mahidol University, Bangkok, Thailand)

Tuesday 1 October 2019

• 13:00 - Spatial enhancer-promoter networks in pluripotent stem cells
  Dr Stefan Schoenfelder (Babraham Institute, Cambridge)

Tuesday 8 October 2019

• 13:00 - Innate host defence: a playing field for the ubiquitin machinery
  Dr Mads Gyrd-Hansen (Ludwig Institute for Cancer Research, Oxford)

Tuesday 15 October 2019

• 13:00 - Does nuclear size matter? Abnormal megakaryocyte polyploidization and maturation in myelofibrosis
  Rong Li (MRC Molecular Haematology Unit, MRC WIMM)

Tuesday 22 October 2019

• 13:00 - Single-cell analysis of structural variations and complex rearrangements with tri-channel-processing
  Dr Jan Korbel (EMBL, Heidelberg, Germany)

Tuesday 5 November 2019

• 13:00 - Predicting the progression of myeloid neoplasms
  Dr Moritz Gerstung (EMBL-EBI, Hinxton, Cambridge)

Tuesday 19 November 2019

• 13:00 - Recent progress towards understanding the molecular mechanism of X chromosome inactivation
  Professor Neil Brockdorff (Department of Biochemistry, University of Oxford)

Tuesday 26 November 2019

• 13:00 - Floor meeting - 2 groups will give an update on the research work in their laboratory
  Dr Robert Beagrie (Prof D Higgs' laboratory, MRC Molecular Haematology Unit), Dr Sarah Gooding (Prof P Vyas' laboratory, MRC Molecular Haematology Unit)

Tuesday 3 December 2019

• 13:00 - Dissecting erythropoiesis in Diamond-Blackfan anaemia at single-cell resolution
  Dr Deena Iskander (Imperial College, London)

Tuesday 17 December 2019

• 13:00 - Re-configuration of chromatin structure during the mitosis-G1 phase transition
  Dr Gerd Blobel (Children's Hospital of Philadelphia, Perelman School of Medicine, Philadelphia, USA)

Tuesday 7 January 2020

• 13:00 - Form and function of the genome: an overview of genomic editing and topology studies
  Professor Wouter de Laat (Hubrecht Institute, University Medical Center, Utrecht, The Netherlands)

Tuesday 4 February 2020

• 13:00 - Dissecting the molecular mechanisms underpinning gene dysregulation caused by a regulatory SNV
  Dr Yavor Bozhilov (MRC Molecular Haematology Unit, MRC WIMM)

Tuesday 11 February 2020

• 13:00 - Ageing and leukemia: synergistic interplay between the hematopoietic system and the bone marrow microenvironment
  Simona Valletta (MRC Molecular Haematology Unit, MRC WIMM)

Tuesday 18 February 2020

• 13:00 - Mining whole genome sequencing for pathogenic copy number and structural variants: the exmaple of craniosynostosis
  Dr Eduardo Calpena (Clinical Genetics, MRC WIMM)

Tuesday 25 February 2020

• 13:00 - Genetic Engineering of Human Hematopoiesis for Treating Inherited Diseases and Cancer
  Status: This talk has been cancelled
  Dr Luigi Naldini (San Raffaele Telethon Institute for Gene Therapy, Milan, Italy)

Tuesday 3 March 2020

• 13:00 - Free Heme overload in DBA progenitors and HSP70/GATA1 involvement in the globin/heme dysequilibrium
  Professor Lydie da Costa (Assistance Publique Hôpitaux de Paris, France)

Tuesday 10 March 2020

• 13:00 - The role of the Chromatin Remodelling factor ATRX in genome stability and cancer
  Dr David Clynes (Dept of Oncology, MRC WIMM)

Tuesday 24 March 2020

• 13:00 - MHU Student Presentations
  SEMINAR CANCELLED
  Xiying Ren, David Cruz Hernandez

Tuesday 31 March 2020

• 13:00 - Too much and not enough: Balancing the scales of haematopoiesis
  SEMINAR CANCELLED
  Dr. Ian Hitchcock (Department of Biology, University of York)

Tuesday 14 April 2020

• 13:00 - Paediatric myeloid leukemia: fusion oncogenes, transcriptional alterations and age specificities
  SEMINAR CANCELLED
  Dr Thomas Mercher (Gustave Roussy, France)

Tuesday 21 April 2020

• 13:00 - Looking under the hood of cells with new microscopy techniques
  SEMINAR CANCELLED
  Dr Jennifer Lippincott-Schwartz (Janelia Research Campus, Virginia, USA)

Tuesday 28 April 2020

• 13:00 - MHU Student Presentations
  SEMINAR CANCELLED
  Joe Harman, Tom Kent, Spencer Tong

Tuesday 12 May 2020

• 13:00 - Tumor exosomes and exomeres promote systemic effects of metastatic cancer
  SEMINAR CANCELLED
  Professor David Lyden (Dept of Pediatrics, Weill Cornell Medical College, NY, USA)

Tuesday 19 May 2020

• 13:00 - Hemodynamics during vascular development – How mechanical forces shape the blood vessels
  SEMINAR CANCELLED
  Professor Elizabeth Jones (Dept of Cardiovascular Sciences, KU Leuven, Belgium)

Tuesday 26 May 2020

• 13:00 - MHU Student Presentations
  SEMINAR CANCELLED
  Jennifer O'Sullivan, Wei Xiong Wen, Caitlin Murnane

Tuesday 23 June 2020

• 13:00 - The cellular and molecular logic of neural tube development
  If you would like to register for this seminar, please email emma.butterfield@ndcls.ox.ac.uk
  Dr James Briscoe (Developmental Dynamics Laboratory, The Francis Crick Institute, London)

Tuesday 30 June 2020

• 13:00 - MHU Student Presentations
  Status: This talk has been cancelled
  Nikolaos Sousos, Grigore Gafencu, Siyu Liu, Yuqi Shen

Tuesday 20 October 2020

• 13:00 - Floor meeting - 2 groups will give an update on the research work in their laboratory
  Various Speakers

Tuesday 27 October 2020

• 13:00 - Floor meeting - 2 groups will give an update on the research work in their laboratory
  Various Speakers

Tuesday 17 November 2020

• 13:00 - Too much and not enough: Balancing the scales of haematopoiesis
  Register via link: https://us02web.zoom.us/webinar/register/WN_W93LSx9UTC-XGg7aHWHomg
  Dr. Ian Hitchcock (Department of Biology, University of York)

Tuesday 1 December 2020

• 13:00 - Floor meeting - 2 groups will give an update on the research work in their laboratory
  Various Speakers

Tuesday 12 January 2021

• 13:00 - Tissue instruction in GVHD and GVL
  Prof Ronjon Chakraverty (University of Oxford)

Tuesday 23 February 2021

• 13:00 - Targeting the reactive oxygen species axis in AML: Redox signalling, proliferation and metabolism
  Dr Alex Tonks (Division of Cancer & Genetics, School of Medicine, Cardiff University)

Tuesday 2 March 2021

• 13:00 - Floor Talk - Patel & Nerlov Labs
  Various Speakers

Tuesday 16 March 2021

• 13:00 - Floor Talk - Milne & Vyas Labs
  Various Speakers

Tuesday 30 March 2021

• 13:00 - Floor Talk - Hughes & Mead Labs
  Various Speakers

Tuesday 6 April 2021

• 13:00 - Paediatric myeloid leukemia: fusion oncogenes, transcriptional alterations and age specificities
  Dr Thomas Mercher (Gustave Roussy, France)

Tuesday 13 April 2021

• 13:00 - Floor Talk - Chapman & Vyas Labs
  Various Speakers

Tuesday 20 April 2021

• 13:00 - Investigating Human Foetal Blood Development at the Single-Cell Level
  Dr Ana Cvejic (University of Cambridge)

Tuesday 27 April 2021

• 13:00 - Floor Talk - Davies & Hughes Lab
  Various Speakers

Tuesday 4 May 2021

• 13:00 - Human haematopoietic landscapes: location matters
  Dr Elisa Laurenti (University of Cambridge)

Tuesday 11 May 2021

• 13:00 - Floor Talk - Jacobsen & Milne Labs
  Various Speakers

Tuesday 18 May 2021

• 13:00 - Stem cells to study human liver development and diseases
  Professor Ludovic Vallier (MRC Cambridge Stem Cell Institute)

Tuesday 25 May 2021

• 13:00 - Floor Talk - Mead & Vyas Labs
  Various Speakers

Tuesday 8 June 2021

• 13:00 - Floor Talk - Chapman & Porcher Labs
  Various Speakers

Tuesday 15 June 2021

• 13:00 - Radiation leukaemogenesis molecular mechanisms in mouse models
  Dr Christophe Badie (Centre for Radiation, Chemical & Environmental Hazards, Didcot)

Tuesday 22 June 2021

• 13:00 - Floor Talk - de Bruijn & Hughes Labs
  Various Speakers

Tuesday 29 June 2021

• 13:00 - Hemodynamics during vascular development – How mechanical forces shape the blood vessels
  Professor Elizabeth Jones (Dept of Cardiovascular Sciences, KU Leuven, Belgium)

Tuesday 6 July 2021

• 13:00 - Floor Talk - Patel & Psaila Labs
  Various Speakers

Tuesday 20 July 2021

• 13:00 - Floor Talk - Hughes Lab
  Various Speakers

Tuesday 7 September 2021

• 13:00 - Floor Talk - Porcher & Vyas Labs
  Various Speakers

Tuesday 14 September 2021

• 13:00 - Activation of platelets by respiratory viruses: lessons learned from human blood
  TBA

Tuesday 21 September 2021

• 13:00 - Floor Talk - Milne & Roberts Labs
  Various Speakers

Tuesday 5 October 2021

• 13:00 - Floor Talk - Higgs & Mead Labs
  Various Speakers

Monday 18 October 2021

• 16:00 - Massively Multiplexed Analysis of Immunobiology
  Asssistant Professor Sean Bendall (Stanford University)

Tuesday 19 October 2021

• 13:00 - MHU Floor Talk - Gibbons/Patel Lab
  Yuqi Shen, Christopher Millington
• 13:00 - Floor Talk - Gibbons & Patel Labs
  Various Speakers

Tuesday 9 November 2021

• 13:00 - Floor Talk - Milne & Porcher Labs
  Various Speakers

Tuesday 16 November 2021

• 13:00 - Bivalency and its Discontents: Reevaluating the role of nucleosomal bivalency in early development
  Associate Professor Alex Ruthenburg (University of Chicago)

Tuesday 23 November 2021

• 13:00 - Floor Talk - Mead & Nerlov
  Various Speakers

Tuesday 7 December 2021

• 13:00 - Floor Talk - Chapman & Roy
  Various Speakers

Tuesday 22 March 2022

• 13:00 - Chemical modulation of enhancers
  Dr Christopher Ott

Tuesday 3 May 2022

• 13:00 - Dr Rui Montero - Developmental haematopoiesis and disease modelling: how zebrafish can help understand bone marrow failure and leukaemogenesis
  Dr Rui Montero (University of Birmingham)

Tuesday 17 May 2022

• 13:00 - Dr Hannah Uckelmann - Mutant NPM1 directly regulates oncogenic gene expression on chromatin in acute myeloid leukemia
  Dr Hannah Uckelmann (Dana-Faber Cancer Institute)

Tuesday 28 June 2022

• 13:00 - A genome-wide relay of signalling-responsive enhancers drives hematopoietic specification
  Professor Constanze Bonifer (Institute for Cancer & Genomic Sciences, University of Birmingham)

Tuesday 12 July 2022

• 13:00 - Biology and therapeutic targeting of cohesin-mutant myeloid malignancies
  Prof Zuzana Tothova (Harvard University)

Tuesday 30 August 2022

• 13:00 - Functional and multiome analysis of human hematopoietic stem cell heterogeneity
  Stephanie Xie (Princess Margaret Cancer Centre, Canada)

Tuesday 6 September 2022

• 13:00 - Design of hematopoietic stem cell culture: Diversity discovery and application
  Satoshi Yamazaki (Uni Tsukuba)

Tuesday 27 September 2022

• 13:00 - A track of the clones: Understanding haematopoietic stem cell identity and function at the single cell level.
  Dr David Kent (University of York)

Tuesday 4 October 2022

• 13:00 - New insights into the Myeloproliferative Neoplasms
  Dr John Crispino (St Jude Children's Research Hospital, USA)

Tuesday 25 October 2022

• 13:00 - Using systems biology to improve childhood leukaemia treatment
  Prof Jonathan Bond (University College Dublin)

Tuesday 8 November 2022

• 12:00 - Developmental origins of haematopoietic stem cells and infant leukaemia
  Dr Katrin Ottersbach (MR Centre for Regenerative Medicine, University of Edinburgh)

Tuesday 6 December 2022

• 13:00 - Clonal determinants of stem cell heterogeneity
  Dr Alejo Rodriguez-Fraticelli (IRB Barcelona)
• 13:45 - Roles of the somite in the instruction of hematopoietic stem cell fate
  Professor David Traver (UC San Diego)

Tuesday 31 January 2023

• 13:00 - Chromatin-based gene regulation in differentiation and disease”
  Dr Robert Beagrie (University of Oxford)

Tuesday 21 February 2023

• 13:00 - The evolutionary dynamics of clonal haematopoiesis and its progression to AML
  Dr Caroline Watson (CRUK Cambridge Centre)

Tuesday 7 March 2023

• 13:00 - Keeping stem cells dormant
  Dr Lev Silberstein (Dept of Molecular & Cellular Biology, Harvard University, USA)

Tuesday 18 April 2023

• 13:00 - Inflamm-Ageing of Hematopoietic Stem Cells
  Prof Markus Manz (Universitäts Spital Zürich)

Tuesday 16 May 2023

• 13:00 - Blood stem cells: a manual to build the engine
  Dr Vincenzo Calvanese (University College London)

Tuesday 6 June 2023

• 13:00 - KMT2A-rearranged acute lymphoblastic leukaemia in infants – an aggressive malignancy with many faces of heterogeneity
  Dr Ronald Stam (Princess Maxima Center)

Tuesday 19 September 2023

• 13:00 - The role of ontogeny in acute myeloid leukaemia
  Dr Karen Keeshan (University of Glasgow)

Tuesday 17 October 2023

• 13:00 - Exploring the potential of single cell proteomics in characterising human HSPCs
  Professor Bo Porse (BRIC, Copenhagen)

Tuesday 7 November 2023

• 13:00 - The rise and fall of oncogenic transcription factor complexes in T-ALL
  Prof Marc Mansour (University College London)

Tuesday 6 February 2024

• 13:00 - Maximising the impact of CAR T-cell therapy for acute leukaemia
  This is a hybrid event - with the speaker attending in-person and viewable on Teams.
  Dr Sara Ghorashian (University College London)

Monday 4 March 2024

• 12:00 - Are all phenotypic hematopoietic cells in the embryo hematopoietic?
  Professor Elaine Dzierzak (MRC Centre for Inflammation Research, University of Edinburgh)
• 13:30 - Mining for gold with AlphaFold: Lessons from genome maintenance
  This is a hybrid event - with the speaker attending in-person and viewable on Teams.
  Professor Johannes Walter (Howard Hughes Medical Institute, Harvard Medical School)

Tuesday 12 March 2024

• 13:00 - Super-enhancer hijacking in acute lymphoblastic leukaemia - from discovery to translation
  This is a hybrid event - with the speaker attending in-person and viewable on Teams.
  Dr Lisa Russell (Newcastle University)

Tuesday 26 March 2024

• 13:00 - Metabolic regulation of hematopoietic and immune functions in aging
  This is a hybrid event - with the speaker attending in-person and viewable on Teams.
  Dr Nicola Vannini (Ludwig Institute for Cancer Research, University of Lausanne)

Tuesday 9 April 2024

• 13:00 - Genetic-based identification of the cellular interactome that supports T-cell development in the thymus
  This is a hybrid event - with the speaker attending in-person and viewable on Teams.
  Dr Miguel Ganuza (Barts Cancer Institute, Ospedale San Raffaele)

Tuesday 23 April 2024

• 13:00 - Using mathematics to understand collective cell behaviours
  This is a hybrid event - with the speaker attending in-person and viewable on Teams.
  Professor Ruth Baker (Mathematical Institute, University of Oxford)

Tuesday 7 May 2024

• 13:00 - Developing in vivo CRISPR system-based technologies to study clonal and malignant haemopoiesis
  Dr Justin Loke (University of Birmingham)

Tuesday 21 May 2024

• 13:00 - The genetics of human leukaemia: A tale of two genomes
  Virtual seminar only
  Professor James Allan (Faculty of Medical Sciences, Newcastle University)

Tuesday 4 June 2024

• 13:00 - Physiological roles of aberrant DNA methylation in vitro and in vivo
  This is a hybrid event - with the speaker attending in-person and viewable on Teams.
  Dr Gabriella Ficz (Barts Cancer Institute)

Tuesday 30 July 2024

• 13:00 - Dissecting the crosstalk between epigenetic gene regulation and DNA damage responses in normal and malignant haematopoiesis
  This is a hybrid event - with the speaker attending in-person and viewable on Teams.
  Professor Eric So (Head, Leukaemia and Stem Cell Biology Group, King’s College London)

Tuesday 17 September 2024

• 13:00 - Tracing the origin of pediatric leukemia using single-cell genome sequencing
  Dr Ruben van Boxtel (Princess Máxima Center)

Tuesday 15 October 2024

• 13:00 - Nucleotide-resolution mapping of regulatory elements in leukemia
  Dr Davide Seruggia (St. Anna Children's Cancer Research Institute)

Tuesday 22 October 2024

• 13:00 - Novel molecular safeguards of healthy and malignant hematopoietic stem cells
  Associate Professor Britta Will (Albert Einstein College of Medicine)

Wednesday 30 October 2024

• 10:00 - Functional genomics of blood formation: Epimutational clones and synthetic enhancers
  Dr Lars Velten (CRG, Barcelona)

Tuesday 26 November 2024

• 13:00 - Transcriptional deregulation in T-ALL
  Jan Cools (Ku Leuven)

Thursday 28 November 2024

• 13:00 - mTOR signaling in growth, metabolism and disease
  Jordan Translational Medicine Lecture 2024: Registration and in-person event only
  Professor Michael Hall (University of Basel)

Tuesday 3 December 2024

• 13:00 - CEBPA mutation disrupting the bZIP domain regulates the epi-transcriptomic landscape to enforce aberrant erythropoiesis and drive disease progression in Myelodysplastic syndromes
  This is a hybrid event - with the speaker attending in-person and viewable on Teams.
  Dr Paloma Garcia (Institute of Cancer and Genomic Sciences, University of Birmingham)

Tuesday 7 January 2025

• 13:00 - Unlocking the potential of a pleiotropic cytokine
  This is a hybrid event - with the speaker attending in-person and viewable on Teams.
  Dr. Ian Hitchcock (Department of Biology, University of York)

Wednesday 8 January 2025

• 11:00 - "Bookending” cancer: the Alpha and Omega of leukaemia evolution
  This is a hybrid event - with the speaker attending in-person and viewable on Teams.
  Prof Brian Huntly (University of Cambridge)

Tuesday 21 January 2025

• 13:00 - Title TBC
  This is a hybrid event - with the speaker attending in-person and viewable on Teams.
  Professor Jean Soulier (Saint-Louise Hospital, France)

Tuesday 4 February 2025

• 13:00 - Title TBC
  This is a hybrid event - with the speaker attending in-person and viewable on Teams.
  Professor Jacob Corn (ETH Zürich)

Tuesday 11 February 2025

• 13:00 - Somatic phylogenies of haematopoietic stem cells to study clonal dynamics and mutagenesis
  This is a hybrid event - with the speaker attending in-person and viewable on Teams.
  Dr Mike Spencer Chapman (Director of Research and Clinical Trials, NHS Digital)

Tuesday 4 March 2025

• 13:00 - Title TBC
  This is a hybrid event - with the speaker attending in-person and viewable on Teams.
  Dr Simon Bomken (Newcastle University)

Tuesday 18 March 2025

• 13:00 - Title TBC
  This is a hybrid event - with the speaker attending in-person and viewable on Teams.
  Dr Michael Milsom (German Cancer Research Centre)

Tuesday 1 April 2025

• 13:00 - Title TBC
  This is a hybrid event - with the speaker attending in-person and viewable on Teams.
  Professor George Vassilou (Cambridge Cancer Stem Cell Institute)

Tuesday 8 April 2025

• 13:00 - Title TBC
  This is a hybrid event - with the speaker attending in-person and viewable on Teams.
  Professor Andreas Trumpp (German Cancer Research Center (DKFZ), Heidelberg)