• Type: Seminar Series
• Series organiser: Charlotte Morgan (University of Oxford)
• Organising department: Structural Genomics Consortium

Thursday 19 February 2015

• 13:00 - Disease genes and 'healthy' human gene knockouts: Genetics for therapeutic innovation?
  Prof. Richard Trembath

Tuesday 24 March 2015

• 13:30 - Target and Polypharmacology Discovery with 3D Models of Everything
  Status: This talk is in preparation - details may change
  Ruben Abagyan (Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego)

Thursday 16 April 2015

• 13:00 - Dynamic protein structure: from protein disorder to membrane pores
  Frank Sobott (University of Antwerp)

Wednesday 24 June 2015

• 09:00 - 4th Oxford Symposium - Epigenetic Mechanisms in Health and Disease New Frontiers in Epigenetics
  Udo Oppermann (University of Oxford), Susanne Muller-Knapp (SGC, University of Oxford), Jorn Walter (Saarland University)

Tuesday 4 August 2015

• 12:00 - Genomics and the nature of schizophrenia
  Prof Mike Owen (Cardiff University)

Thursday 29 October 2015

• 09:30 - Flow Chemistry: Opening Up New Chemistry Frontiers
  Richard Jones (ThalesNano)

Tuesday 10 November 2015

• 13:00 - Super-resolution optical microscopy: Current state-of-the-art of biomedical applications
  Prof Christian Eggeling (University of Oxford)

Friday 15 January 2016

• 13:00 - Voltage-gated calcium channels and their roles in disease
  Annette Dolphin (University College London)

Wednesday 20 January 2016

• 13:45 - New insights into LRRK2 and SGK3 signalling pathway and relevance to Parkinson’s disease and cancer
  Dario Alessi (University of Dundee)

Wednesday 1 June 2016

• 12:00 - “Imaging proteins at the single molecule level”
  Jean-Nicolas Longchamp (University of Zuerich)

Wednesday 7 September 2016

• 15:00 - The development of Keap1-interactive compounds that regulate Nrf2 transcriptional activity
  Dr Geoff Wells (University College London)

Monday 19 September 2016

• 15:00 - Birth of the Cool: Multitemperature Multiconformer X-Ray Crystallography and Allostery
  Dr James Fraser (UCSF)

Friday 30 September 2016

• 13:45 - Advanced Chemical Genetics for Epigenetics: Bump-and-hole and PROTACs
  Dr. Alessio Ciulli (University of Dundee)

Wednesday 5 October 2016

• 13:00 - Epigenetic Targets for the Treatment of Human Diseases
  All welcome.
  Rab Prinjha (GSK Biology Council)

Wednesday 26 October 2016

• 13:00 - Regulation of polyA tail length by cellular machines
  Lori Passmore ( MRC Laboratory of Molecular Biology)

Monday 7 November 2016

• 14:30 - Biological imaging and ultrafast spectroscopy facilities in the Research Complex at Harwell, and their role in the study of structure/function relationships of EGF receptor complexes
  Prof MarisaProf. Marisa Martin-Fernandez (Harwell), Dr Dave Clarke (Harwell)

Monday 21 November 2016

• 12:30 - Informatics methods for understanding drug action
  Prof Russ Altman (Stanford University)

Wednesday 14 December 2016

• 14:00 - Identification of novel functional sites in protein domains from the analysis of human variation
  Prof Geoff Barton (Dundee University)

Monday 16 January 2017

• 11:00 - HCN2 ion channels – drivers of chronic pain and tinnitus
  Prof Peter McNaughton (King's College, London)

Wednesday 25 January 2017

• 12:30 - Opportunities and Challenges for Drug Development in ALS.
  Dr Lucie Bruijn (Chief Scientist, ALS Association (USA))

Tuesday 14 February 2017

• 10:00 - Phase contrast cryo-electron microscopy
  Maryam Khoshouei (Max Plank Institute of Biochemistry, Germany)

Wednesday 22 February 2017

• 13:00 - Pioneering- one of our core values and how it influences everything we do
  David Jenkinson (Chief Scientist, The Brain Tumour Charity)

Thursday 16 March 2017

• 13:00 - Protein Folding Machines- Molecular Machines for Complex Problems
  Kelly Knee (Pfizer)

Wednesday 12 April 2017

• 13:00 - Biophysical characterization of G6b-B: advancing the field of ITIM receptors
  Prof Yotis Senis (University of Birmingham)

Friday 28 April 2017

• 13:00 - A vision for an academic-industry hybrid type 2 diabetes early biology research institute in Oxford
  Prof Jim Johnson (The University of British Columbia)

Wednesday 10 May 2017

• 13:00 - Public Private Partnerships at NIH’s National Center for Advancing Translational Sciences (NCATS) to Translate Promising Therapies into Treatments for Rare and Neglected Diseases
  Dr Nora Yang (NIH, USA)

Monday 15 May 2017

• 10:30 - "Vaccination against chronic diseases" by Prof Bachmann & “VLP Vaccine approach for Parkinson’s Disease” by Dr. El-Turabi
  Prof Martin Bachmann (Jenner Institute), Dr. Aadil El-Turabi (Jenner Institute)

Tuesday 23 May 2017

• 11:00 - Modelling breast cancer using human tumour explants
  Prof Carlos Caldas (CRUK Cambridge Institute)

Thursday 8 June 2017

• 13:00 - From Protein Complexes Structures to Synthetic Viral Nanosystems
  Prof Imre Berger (University of Bristol)

Monday 10 July 2017

• 11:00 - Towards a Comprehensive Structural Understanding of BCR-ABL Tyrosine Kinase Complexes
  Prof Oliver Hantschel (ISREC)

Friday 21 July 2017

• 13:30 - Molecular mechanisms of DNA replication revealed by structural studies
  *This talk has been cancelled - will be rescheduled for after summer*
  Status: This talk has been cancelled
  Prof Luca Pellegrini (University of Cambridge)

Monday 31 July 2017

• 11:00 - NGL – a molecular graphics library for the web
  Dr Alex Rose (RCSB PDB, USA)

Friday 11 August 2017

• 15:00 - Identifying tomorrow’s hepatocellular carcinoma patients’
  Dr Rajarshi Banerjee (CEO of Perspectum Diagnotics)

Wednesday 20 September 2017

• 13:00 - Global Biochemical Profiling for Problem Solving in Biology and Disease
  Prof Chris Schofield (Head of Organic Chemistry, Univ Oxford)

Tuesday 26 September 2017

• 11:00 - Phosphorylation-dependent assembly of DNA damage response complexes’
  Prof Laurence Pearl (Sussex University)

Monday 23 October 2017

• 11:00 - A mass spectrometric view on epigenetic and phosphorylation based signalling systems
  Dr Matthias Gstaiger (Institute of Molecular Systems Biology, ETH Zürich )

Wednesday 29 November 2017

• 16:00 - Global Biochemical Profiling for Problem Solving in Biology and Disease
  Saul H. Rosenberg, PhD. (Senior Director of Oncology Discovery at AbbVie)

Friday 8 December 2017

• 13:00 - Molecular mechanisms of DNA replication revealed by structural studies
  Prof Luca Pellegrini (Cambridge University)

Tuesday 16 January 2018

• 13:00 - GraDeR: detergent free membrane protein preparation
  Ass. Prof. Christoph Gerle (Laboratory of Protein Crystallography, Institute for Protein Research, Osaka University)

Monday 19 February 2018

• 13:00 - Human stem cells for drug discovery
  Dr Nicola Beer (Head of the Department of Stem Cell Engineering at Novo Nordisk Research Centre Oxford)

Friday 2 March 2018

• 13:00 - Bringing a structural perspective to antimicrobial resistance; can we predict whether individual mutations confer resistance or not?
  CANCELLED DUE TO WEATHER CONDITIONS.
  Status: This talk has been cancelled
  Dr Philip Fowler (Experimental Medicine Division, Nuffield Department of Medicine, John Radcliffe Hospital)

Tuesday 13 March 2018

• 13:00 - Dr P McPherson "Intracellular membrane trafficking in neurological disease", & Dr T Durcan "Open science meets Stem cells: A new approach for developing therapies against disorders of the brain"
  Dr Peter McPherson (McGill University), Dr Thomas Durcan (McGill University)

Thursday 15 March 2018

• 14:00 - Cryo-EM structures illuminate binding sites and gating mechanisms in the pancreatic Katp channel.
  Gregory Martin (Oregon Health & Science University Portland (OR), USA)

Friday 23 March 2018

• 10:30 - From mucolipidosis type IV to Ebola: insights into function and pharmacology of endolysosomal cation channels
  Dr Christian Grimm (Ludwig-Maximilians-Universität (LMU))

Friday 6 April 2018

• 11:00 - Therapeutic targets in Ageing
  Status: This talk has been cancelled
  Professor David Le Couteur (The University of Sydney)

Friday 27 April 2018

• 13:00 - Understanding and treating lysosomal diseases
  Prof Frances Platt (Department of Pharmacology, University of Oxford)

Tuesday 12 June 2018

• 15:00 - The history and use of DNA-Encoded Libraries in drug discovery
  Dr Barry Morgan (CSO HitGen, Boston, USA)

Friday 23 November 2018

• 13:00 - Studying drug effects on the Proteome
  Marcus Bantscheff (Head of Technology, Cellzome A GSK company)

Friday 7 December 2018

• 13:00 - A detergent free solution to the age old problem of membrane protein extraction
  Professor Tim Dafforn (University of Birmingham)

Wednesday 13 February 2019

• 13:00 - Iterative Stochastic Elimination Algorithm for drug discovery by targeting and multitargeting
  Prof Amiram Goldblum (Hebrew University of Jerusalem School of Pharmacy)

Thursday 25 April 2019

• 15:00 - Hidden treasures of the RNA World: from moonlighting to riboregulation
  Prof Matthias Hentze (Director of the European Molecular Biology Laboratory (EMBL) and Co-Director of the Molecular Medicine Partnership Unit (MMPU))

Tuesday 30 July 2019

• 13:00 - Patient positioning: How to take an oncology drug into the clinic
  Dr Sarah Blagden (Department of Oncology, Univeristy of Oxford)

Monday 4 November 2019

• 13:00 - Signalling with ubiquitin — communication between metabolism, immune responses and DNA damage repair
  Dr Elton Zeqiraj (University of Leeds)

Tuesday 26 November 2019

• 11:00 - Host-directed therapies for tuberculosis targeting macrophage activation and stress resilience
  Prof Igor Kramnik (University of Boston)

Thursday 13 February 2020

• 13:00 - Quantitative Proteomics
  Dr. Holger Kramer (MRC London Institute of Medical Sciences)

Tuesday 3 November 2020

• 13:00 - Quantitative Proteomics
  Dr Holger Kramer (MRC London Insitute of Medical Sciences)

Wednesday 20 January 2021

• 13:00 - Accelerating Treatments for Alzheimer’s Disease
  Dr Allan Levey (Emory University)

Wednesday 3 February 2021

• 13:00 - How Best to Explore Chemical Space for Bioactive Molecular Discovery?
  Adam Nelson (University of Leeds)

Tuesday 9 February 2021

• 13:00 - An introduction to metabolomics: Investigating cellular function and determining novel drug targets for disease
  Professor James McCullagh

Wednesday 17 February 2021

• 13:00 - Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Cancer
  Cigall Kadoch (Dana Farber Institute)

Wednesday 3 March 2021

• 13:00 - Targeting subcellular trafficking pathways for the design of therapeutic antibodies
  Professor E. Sally Ward (University of Southampton)

Wednesday 14 April 2021

• 13:00 - Structure of the human citrate transporter NaCT
  David Sauer (NYU School of Medicine)

Wednesday 28 April 2021

• 13:00 - Combining computational modelling, structural biology and immunology to understand Antigen processing
  Prof Tim Elliott (University of Oxford)

Tuesday 25 May 2021

• 13:00 - Identifying new targets in cardiometabolic disease
  Professor Keith Channon

Wednesday 26 May 2021

• 13:00 - Accelerating medicinal chemistry with hypothesis-driven machine learning
  Dr Alpha Lee (University of Cambridge)

Wednesday 9 June 2021

• 13:00 - SHIP1 is necessary for tumor surveillance
  Professor William Kerr (Empire Scholar State University of NY)